iPSC-derived brown-like adipocytes progenitors as a new tool for drug discovery?

Interesting paper from Christian Dani team about the potential of Brown and brown-like adipocytes (BAs) proginitors derived from hiPSCs to dissipate energy stored and the promising potential to treat obesity and metabolic disorder. In this publication, they describe the capacity of human-induced pluripotent stem cells (hiPSCs) to generate BAPs able Read more…

A biomimetic hydrogel functionalized with adipose ECM components as a microenvironment for the 3D culture of human and murine adipocytes

Abstract The lack of relevant in vitro models for adipose tissue makes necessary the development of a more physiological environment providing spatial and chemical cues for the effective maturation of adipocytes. We developed a biofunctionalized hydrogel with components of adipose extracellular matrix: collagen I, collagen VI, and the cell binding Read more…