Applications for 3D in vitro models with BIOMIMESYS® Adipose Tissue

3D cell culture systems have recently emerged as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). BIOMIMESYS® hydroscaffold technology based on crosslinking Hyaluronic Acid (HA) and extracellular matrix compounds reproduces tissue microenvironment Read more…

BIOMIMESYS® Adipose tissue

Regulation of lipid accumulation : application with BIOMIMESYS® Adipose tissue

Retinoic acid and Caffeine are reference molecules known for their inhibitory activity on lipogenesis. Retinoic acid, a derivative of vitamin A, inhibits adipogenesis by blocking adipogenic factors such as PPARγ2 and C / EBPα, via the Retinoic acid receptor (RAR) ligand (1). Caffeine, a non-selective adenosine antagonist receptor, is used Read more…

A chemotaxis-based explanation of spheroid formation in 3D cultures of breast cancer cells

New results of growing of breast cancer (MCF7 and MCF7-sh-wisp2) cells in BIOMIMESYS® Adipose tissue as a relevant 3D in vitro model, using Keller–Segel PDE system to model chemotactical auto-organization of cells. Abstract Three-dimensional cultures of cells are gaining popularity as an in vitro improvement over 2D Petri dishes. In many such experiments, Read more…