We are pleased to welcome Natacha Perrin in our laboratory for a 6-month internship. Natacha is currently in last year of engineering school in Polytech Clermont. This year, in parallel of her initial formation, she also did a double degree in pharmacy. During her studies, she had the opportunity to Read more…
About 90% of drug candidates fail in clinical trials, for efficacy- and toxicity-related reasons, which often involve the Central Nervous System (CNS). This high failure rate highlights a lack of relevance in experimental models used upstream, including human in vitro models. Indeed, they do not take into account the complexity Read more…
In the brain, we have about 100 billion of neurons but they represent only 10 to 50% of the total cells (von Bartheld et al., 2016). Indeed, glial cells, including astrocytes, oligodendrocytes and microglia are also essential to the physiological functions of the brain. Parkinson’s Disease (PD) is the secondary Read more…
Parkinson’s disease affects more than 6 million people worldwide. This neurodegenerative disease is characterized by the death of dopaminergic neurons in the substantia nigra pars compacta, with intracellular accumulation of alpha-synuclein aggregates known as Lewi bodies. This neuronal loss leads to a decrease in the neurotransmitter dopamine that cause mainly Read more…