Next week HCS Pharma will be present at SFBMEc Reims (15th-17th May). We will present a poster about the influence of BIOMIMESYS® hydroscaffold composition and stiffness on the 3D culture of breast cancer cells. The poster will be avalaible next week, but if you want it before, you can contact Read more…
The annual SCMC congress (Société Cerveau et Maladies Cérébrovasculaires – Brain and Cerebrovascular diseases Society) took place in Lille last week, in the Faculty of Medecine. The congress was organized in three sessions. The first session was about cerebrovascular development and maturation. The conferences began with a lecture about blood-brain Read more…
Last week HCS Pharma team enjoyed Forum Labo Paris! We enjoyed it twofold because : we won our booth on the Lab’StartUp Village, in the heart of the fair. It gave us the opportunity to present our BIOMIMESYS® products! we won a price for our amazing photo of liver cells… Read more…
Next week HCS Pharma will be present both at Forum Labo Paris (26th-28th March ) and at SCMC congress in Lille (28-29th March)! In Forum Labo we will have our own stand in the Lab’StartUp Village (stand G11), thanks to the organizers for selecting BIOMIMESYS® Brain for the fair! We Read more…
Victoria has joined us for a six-month internship in collaboration with the University of Technology of Compiègne. She will develop a liver biochip, using the BIOMIMESYS® Liver hydroscaffold. Victoria obtained her bachelor’s degree in Cellular Biology and Physiology. Currently she is finishing the 2nd year of Master’s Degree in Biotechnologies Read more…
The first version of BIOMIMESYS Brain allows to form neurospheres. We now developped a new version of BIOMIMESYS Brain, which allows to form neuronal networks. This version have a higher porosity than BIOMIMESYS Brain (Neurosphere), that allows to better disperse the cells and thus to form cell network instead of Read more…
BIOMIMESYS® Oncology is mostly composed of hyaluronic acid (HA), biofunctionnalized with undenaturated collagen I. HA, by interacting with its binding proteins (CD44, RHAMM, ICAM-1), is an active participant in inflammatory, angiogenic, fibrotic and cancer-promoting processes (Figure 1). We are currently looking at the effect of different elastic moduli of BIOMIMESYS® Read more…
We were really happy to participate in SLAS2019 in Washington last week. In addition to spending a few relaxing days in Washington, we enjoyed the warm welcome of the US team of Molecular Devices. We had the opportunity to present HAPIx, our HCS robotic platform fully designed and integrated by Read more…
HCS Pharma is one of the winner of the Lab’StartUp village, organized by Forum Labo! As such, we have won a stand in the heart of the forum (March 26-28, 2019)… Thanks a lot to the committee for evaluating our application to this prize, and for selecting our new product Read more…
Extracellular matrix (ECM) is known to have an influence on physiological processes and on tumour progression: ECM properties (composition, stiffness) modulate cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT). For example, EMT is inhibited by laminin-rich environment whereas it is promoted in fibronectin-rich ECM (Chen et al 2013. Differentiation 86, Read more…
Most potential drug candidates (90%) fail within the clinical trials, mainly because of lack of efficacy. What if the pharmaceutical industry uses predictive human in vitro models in early drug discovery ? Ask for a high quality version of this poster : View and download on Slideshare (low quality) https://fr.slideshare.net/hcspharma/a-groundbreaking-3d-cell-culture-technology-for-hcs-biomimesys-hydroscaffold
A new BIOMIMESYS® hydroscaffold is available for 3D cell culture! This hydroscaffold is suitable for neuronal cell culture. We tested it for two cell lines: SH-SY5Y cells, commonly used for pharmaceutical research, and LUHMES cells (dopaminergic neurons). Cells grow and form spheroids with intra and inter-spheroidal neurites. BIOMIMESYS® hydroscaffold allows Read more…
We are very happy to wish you a wonderful year 2019!
Nous sommes très heureux de vous souhaiter une excellente année 2019 !
Sood et al. published in 2016 an interesting article about the effect of extracellular matrix (ECM) on in vitro neuronal cells culture: “Fetal brain extracellular matrix boosts neuronal network formation in 3D bioengineered model of cortical brain tissue “. The aim of the study was to study the effects of Read more…
We are developing a new BIOMIMESYS® hydroscaffold for neuronal cells. First results are very promising because neurons grow and form neurites. Moreover cells lived longer than in monolayer culture. We are currently finalizing this new hydroscaffold to find the best conditions of 3D neuron culture, but BIOMIMESYS® Brain will be soon Read more…
In this article, researchers from Sorbonne University (Paris, France) proposed an explanation for the patterns followed by breast cancer cells when seeded in BIOMIMESYS, i.e. spherical aggregates. Usually, mathematical models dealing with the formation of patterns by cells in the extracellular matrix do not take into account the chemical environmental Read more…
Hyaluronan or Hyaluronic Acid (HA) is a ubiquitous constituent of extracellular matrix (ECM) and, because of its excellent intrinsic biocompatibility and chemical or enzymatic modification versatility, has been widely employed in a multitude of biomedical of biotechnological applications. In this interesting article from Serban et al. they will investigate the approaches Read more…
The 20th International Congress on In Vitro Toxicology (ESTIV2018) is coming and it will be a great occasion for HCS-Pharma to showcase our current co-development, with the institute du thorax of Nantes and the RHU CHOPIN, on the use of hepatocyte-like cells differentiated from human induced pluripotent stem cells (hiPSC) Read more…
In HCS Pharma we strongly believe that 3D is the right way to improve drugs dicovery processes. It’s why we develop our 3D hydroscaffold matrix BIOMIMESYS® for 3D cell culture and we invest in 3D pictures acquisition (and analyse) with our partner Molecular Devices. Then we are very please to Read more…
Cells have diverse circuitry to sense and respond to extrinsic metabolic signals. Extracellular matrix (ECM) reorganization which is central to both tissue expansion and regeneration. ECM remodeling is also a signature of pathological processes, such as tumorigenesis. In this study from Sullivan et al., they show that increased migration in Read more…
Nos différents produits BIOMIMESYS® sont disponibles depuis le début de cette année et nous attachons beaucoup d’importance aux retours de nos clients, à leurs remarques et à leurs questions. Pour simplifier la communication avec notre communauté d’utilisateurs, nous avons mis en place une F.A.Q. (Frequently Asked Questions) sur notre site Read more…
“Regulation needs to catch up with innovation.” Henry Paulson – CEO Goldman Sachs A very nice state of art about animal testing and its alternatives can be found in the new article “Animal Testing and its Alternatives – the Most Important Omics is Economics” from Hartung et al. This study established that Read more…
HCS pharma has organized its second scientific advisory board! We were pleased to gather around the table (physically or via a Webex visioconference for those who could not make the trip) David Devos, Roméo Cecchelli, George Haase, Karim Si Tayed… and a new board member: Dominique Collard! Dominique is known Read more…