Application Notes
Simplifying 3d cell culture generation for high content screening with BIOMIMESYS® and the Viaflo 96-384 (with Integra Biosciences)
Growing interest in phenotypic screening, together with evidence that the drug response of cells grown in three-dimensional (3D) structures more closely resembles in vivo activity, has made high throughput, 3D fluorescence imaging an attractive screening option for drug discovery. However, creating 3D spheroids compatible with high content screening can be Read more…
Biomimesys
Meryl defended his doctoral thesis about pluripotent stem cells, liver and BIOMIMESYS®
We are very pleased to announce that Meryl, our first CIFRE PhD student, defended his doctoral thesis last week! His PhD work was dealing with the use of pluripotent stem cells to study liver diseases. He has also developed an innovative model to obtain liver organoïds in our BIOMIMESYS® product. Read more…
Biomimesys
New 384-well plates format for BIOMIMESYS® Liver & Oncology entitling Cell-Based Assays High-Throughput Screening
HCS-Pharma is pleased to launch BIOMIMESYS® Liver and Oncology in ready-to-use 384-well plate format for screening applications. Adopt BIOMIMESYS® 3D cell culture systems and obtain more predictive in vitro models. You can find our presentations in PDF format for BIOMIMESYS® Liver for BIOMIMESYS® Oncology For more information, contact us at hello@biomimesys.com
Biomimesys
An innovative three dimension (3D) cell culture system mimicking in vivo conditions
HCS Pharma is pleased to present the whole range of BIOMIMESYS® Products. All our scientific team is ready to support you in using our 3D organ/tissue-specific cell-culture technology. Rediscover your cells in real in vitro 3D-culture conditions with our special evaluation plate format . You can find our presentation in Read more…
Biomimesys
Our involvement in preclinical breast cancer research
On the occasion of the breast cancer awareness month, HCS Pharma is willing to thank all researchers working in the field to better understand the pathophysiology of disease, with the objective to find more efficient anti-cancer therapies. We would like to warmly thank the researchers with whom we are collaborating Read more…
News
Vaihere joins us as a lab technician
Vaihere Cheung obtained her technology A-level (STL) in 2018 at La Mennais, in French Polynesia. Then she came to metropolitan France to reach a technician diploma in Biological engineering, specialized in biological and biochemical analysis, at the University of Lyon. During her studies, Vaihere did an internship in HCS Pharma Read more…
Biomimesys
Thomas joins us to work on breast cancer
It’s pleasure to welcome Thomas in our team. After a four-month internship at the CrCHUM (Centre de recherche du Centre Hospitalier de l’Université de Montréal, Canada) in the field of microfluidic personalized medicine for prostate cancer, he joined us in September for a six- months-internship, as part of his Master’s Read more…
HCS, HCA & Biology
Cell-ECM Mechanobiology: why interdisciplinary fields?
Cells and the extracellular matrix (ECM): what is the relationship between them? This is a fundamental question. We hear many reflections about this question. Should we let cells work alone, or should we force cells to form an aggregate when working in vitro? Do cells need a specific and relevant Read more…
Biomimesys
Great success for BIOMIMESYS® presentation at Academia Sinica (Taiwan)
We are really proud to work on a real partnership with the team of Tokyo Future Style (TFS) Taïwan for almost a year now. Joseph Chou, member of our business advisory board and Pr John Lo, member of our scientific advisory board, have fully understood the value of BIOMIMESYS® our Read more…
Biomimesys
BIOMIMESYS® for assessing anti-cancer treatments
This summer, Vitali et al. published an article in the Open Access Journal Cancers in which they assessed anticancer combination to treat neuroendocrine tumors (NETs) using in vitro models (2D + 3D cultures in BIOMIMESYS hydroscaffolds). A NET arises in the specialized cells of the neuroendocrine system, which have traits of Read more…
HCS, HCA & Biology
Hyaluronic Acid : structure – function relationship
In the continuity of our scientific reviews about the important roles of Hyaluronic Acid (HA) in extracellular matrix (ECM) and cell behavior, we herein present this recent review describing the structure – function relationship of HA. As an important polysaccharide of ECM, HA plays an important role in cell and Read more…
Biomimesys
Vaihere joins us to work on cerebral in vitro model including microenvironment
Vaihere Cheung obtained her technology baccalaureate in Sciences and Laboratory Techniques (STL) in 2018 at La Mennais, in French Polynesia. Afterwards, she came to Metropolitan France to pursue her studies in biological engineering at the Technological Institute in Lyon University. In this context, she performed an internship in two laboratories Read more…
Biomimesys
Discover BIOMIMESYS® uses with Dr Cécile Legallais (Laboratory of Biomechanics & Bioengineering – CNRS / UTC)
It’s a great pleasure to present you this discussion with Dr Cécile Legallais about her use of BIOMIMESYS® technology. We thank her for her time and her disponibility despit the COVID-19 lockdown. You can find below the translation in French and English (and you can change captions on the video) Read more…
Biomimesys
ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma
Abstract The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in osteosarcoma, because it effluxes doxorubicin, reducing the intracellular accumulation, toxicity, and immunogenic cell death induced by the drug. The ATP Binding Cassette transporter A1 (ABCA1) effluxes isopentenyl pyrophosphate (IPP), a strong activator of anti-tumor Vγ9Vδ2 T-cells. Recruiting this population Read more…
News
Karine Hannebique, surgeon on breast cancer, joins our Scientific Advisory Board
Dr. Karine Hannebicque has joined our Scientific Advisory Board. She is a surgeon in breast cancer and reconstructive surgery working in Oscar Lambret Center in the Department of breast oncology since 2013. She is also Medical Coordinator of the Ambulatory Surgery Unit since 2018. After her Internship in Obstetrics & Read more…
Biomimesys
Feedback from Molecular Devices’ User Meeting in Leiden
Just before Covid-19 pandemic crisis widely spread to France, we attended the User Meeting organized by Molecular Devices in Hilton Garden Inn Leiden (Oegstgeest, Netherlands). We enjoyed the programme, gathering a variety of topics but with high content analysis/screening as a common technique to answer diverse scientific questions. On the Read more…
News
COVID-19 pandemic impacts HCS Pharma activities
As many companies in France and in the world, the COVID-19 pandemic deeply affects our activities. For safety reasons, most of our work is now done remotely but we maintain essential activity in laboratories to take care of our cells and try to finish our ongoing customer studies. The situation Read more…
News
We will attend HCS User Meeting by Molecular Devices in Leiden next week
We will give a presentation next week (on Tuesday, 10th of March 2020) at the High-Content Cellular Imaging User meeting organized by our partner Molecular Devices, which will take place in Leiden (Netherlands). It is a great pleasure for us to attend the meeting, and to talk about the applications, Read more…
News
Meet Meryl in Rennes at the next “Liver Week”
The 8th edition of the Symposium of “Functional Genomics of the Liver” (GFF) will be held from 26 to 28 February 2020 in Rennes, at the Couvent des Jacobins. Meryl, from our team, will be present with a poster about hiPSCs-derived liver organoids made with BIOMIMESYS® Liver hydroscaffold. If you Read more…
BioPharMEMS
LabCom grant for HCS Pharma, SMMiL-E team and IEMN
We are happy to tell you that HCS Pharma, SMMiL-E team (Seeding Microsystems in Medecine in Lille – European-Japanese Technologies against Cancer, CNRS UMI-2820 LIMMS/IIS) and Institut d’Electronique, de Micro-Electronique et de Nanotechnologie (IEMN) have successfully applied to a LabCom grant (‘COMmon LABoratory’)! A LabCom aims at gathering two entities Read more…
Biomimesys
New tutorials and new support section to facilitate your BIOMIMESYS® uses!
We often talk about our innovative product BIOMIMESYS® here to explain how we (and others!) us it in many cases. You can imagine that 3D cell culture with this product is complicated or that you have to spend a lot of time in training. But it’s actually quite simple to Read more…
HCS, HCA & Biology
Mechanical stress on cells observed in cancerous tumor can be reproduced with BIOMIMESYS® hydroscaffold
It is now well described that in tumor biopsies, the stiffness of the cancerous tissue is higher than the surrounding non-cancerous tissue of the same organ, with a described remodeling of the ECM. The increase in rigidity is related to the stimulation of fibroblasts that increase the synthesis of glycosaminoglycans, Read more…