Impact of neurodegenerative diseases on extracellular space organization and diffusion through hyaluronan remodeling

Soria et al. has published this year an interesting study about the modification leading by synucleopathy on the nanoscale organization and diffusivity of the extracellular space, through hyaluronan remodeling. Indeed the extracellular space (ECS), composed by the interstitial fluid and the extracellular matrix (ECM), plays several roles in health and Read more…

3D co-culture of dopaminergic neurons and astrocytes in BIOMIMESYS® Brain to study Parkinson’s disease

Parkinson’s disease affects more than 6 million people worldwide. This neurodegenerative disease is characterized by the death of dopaminergic neurons in the substantia nigra pars compacta, with intracellular accumulation of alpha-synuclein aggregates known as Lewi bodies. This neuronal loss leads to a decrease in the neurotransmitter dopamine that cause mainly Read more…

What’s new about Blood Brain Barrier? Feedback from the annual Congress of the SEISC

The annual meeting of the Society for the Study of Blood Brain interface (SEISC) took place in Paris the 9th November 2018. All day long, recent studies adressing different BBB issues have been presented, including Blood-Brain Barrier (BBB) development, molecular control, and several pathological aspects. BBB development: The meeting started Read more…