Thursday, 16th June will take place the annual congress of the SCMC (Societe Cerveau et Maladies Cerebrovasculaires – Brain and cerebrovascular diseases Society) in Paris. It is our pleasure to participate to this event! Indeed, our project director Elodie Vandenhaute will be present as secretary of the association and organizer Read more…
In the context of NanoStem Project, a Marie-Curie Innovative Training Network project funded by the European Union’s Horizon 2020, and in collaboration with HCS Pharma, Elisa L.J. Moya defensed successfully her PhD the 15th December 2021 in Université d’Artois (Lens, France) about the miniaturization and automation of a well-established human Read more…
About 90% of drug candidates fail in clinical trials, for efficacy- and toxicity-related reasons, which often involve the Central Nervous System (CNS). This high failure rate highlights a lack of relevance in experimental models used upstream, including human in vitro models. Indeed, they do not take into account the complexity Read more…
2022 is beginning, but 2021 ended in the most beautiful way… with Véronique De Conto‘s PhD defense. She successfully defended her PhD thesis about the importance of the microenvironment in cerebral in vitro models for phenotypic screening. We had the privilege to maintain the PhD defense on-site, even if one member Read more…
2D cell culture has been used for more than 100 years now, to keep cells outside of their original organism and to use them for different purposes. It is still widely used in research and early steps of the drug discovery process, and has allowed a bunch of discoveries so Read more…
As you might know, October is the Breast Cancer Awareness Month, an annual campaign to raise awareness about the impact of breast cancer. Research is the key tool to fight this disease and we are very happy to collaborate with amazing research teams in this fight. Since last year, our Read more…
Since the beginning of this year we have created four webinars to present our BIOMIMESYS® technology and practical uses. We have chosen to focus on the scientific side of our innovation by presenting results in drug discovery or dermocosmetology domains. Theses four webinars are available on our support page (with many Read more…
Pharmaceutical industry is facing a very high failure rate in drug discovery, with 90% of failure in clinical trials. This is particularly true for central nervous system applications, with a rate of 30% safety failure in clinical trials, compared to 7% in preclinical trials (Cook et al. 2014). This reveals Read more…
The annual congress of the SCMC (Societé Cerveau et Maldies Cérébraux Vasculaires – Brain and cerebrovascular diseases Society) will take place this Friday, may 28 2021 (virtual congress). On this occasion, our PhD student Véronique De Conto will present her PhD works, which concern the development of new cerebral in Read more…
Ask for high quality link by putting your email below There is a 90% failure in clinical trials, due to efficacy and safety issues, which frequently concerns the central nervous system. That points a lack of relevance of preclinical models used upstream. In this frame, the aim of this study Read more…
The international NeuroFrance congress will take place May, 19, 20 and 21th 2021 (virtual meeting). On this occasion, our PhD student Véronique De Conto will present these works in a poster about the importance of matricial and cellular microenvironment for drug discovery in Parkinson’s disease (summary below). Feel free to Read more…
When Tuesday, June 1, 2021 – 1PM (CET) / 8PM (CST) / 9PM (JST) / 7AM (EST) Thursday, June 3, 2021 – 9AM (CET) / 4PM (CST) / 5PM (JST) / 3AM (EST) Where Online, using zoom.us and live on Youtube What Pharmaceutical industry is facing a very high failure rate in Read more…
Soria et al. has published this year an interesting study about the modification leading by synucleopathy on the nanoscale organization and diffusivity of the extracellular space, through hyaluronan remodeling. Indeed the extracellular space (ECS), composed by the interstitial fluid and the extracellular matrix (ECM), plays several roles in health and Read more…
Parkinson’s disease affects more than 6 million people worldwide. This neurodegenerative disease is characterized by the death of dopaminergic neurons in the substantia nigra pars compacta, with intracellular accumulation of alpha-synuclein aggregates known as Lewi bodies. This neuronal loss leads to a decrease in the neurotransmitter dopamine that cause mainly Read more…
Vaihere Cheung obtained her technology A-level (STL) in 2018 at La Mennais, in French Polynesia. Then she came to metropolitan France to reach a technician diploma in Biological engineering, specialized in biological and biochemical analysis, at the University of Lyon. During her studies, Vaihere did an internship in HCS Pharma Read more…
The human brain contains approximately 86 billon neurons of different types, distributed and organized in different areas ; their functions vary according to the neuron type and its localization within the brain. However, the neuronal function also depends on its microenvironment, which is composed of the extracellular matrix (ECM), and Read more…
Elisa Moya started her bachelor’s degree in 2013, in Biological Sciences, at the University of Granada, Spain. During her career period, in 2015, she studied one year in Portugal (Erasmus+). Moreover, in the summer 2016, she participated during 3 months in a research project dealing with Alzheimer’s disease in Newcastle Read more…
The extracellular matrix (ECM) is composed of macromolecules surrounding the cells. They interact with each other and with the cells, cross-link and polymerize, ensuring the maintenance and the function of organs. The primary role of ECM is to support the cells by providing adhesion support, but its role goes beyond: Read more…
James W. Fawcett published the review « The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease » in 2015, highlighting the key role of the chondroitin sulfate proteoglycans (CSPGs) of the extracellular matrix (ECM) in brain plasticity. CSPGs are present in the brain extracellular matrix and Read more…
The annual congress of Biology and Health PhD students from Lille (André Verbert day) took place at the Faculty of Medicine Thursday, September 10th. During this day, PhD students, in third year of thesis, had to present their works by talks, flash-talks or posters. Our PhD student Véronique De Conto Read more…
