BIOMIMESYS® Oncology is a relevant hydroscaffold for cancer-related in vitro studies

BIOMIMESYS® Oncology is mostly composed of hyaluronic acid (HA), biofunctionnalized with undenaturated collagen I. HA, by interacting with its binding proteins (CD44, RHAMM, ICAM-1), is an active participant in inflammatory, angiogenic, fibrotic and cancer-promoting processes (Figure 1). We are currently looking at the effect of different elastic moduli of BIOMIMESYS® Read more…

Influence of the extracellular matrix on cancer cell proliferation and migration

Extracellular matrix (ECM) is known to have an influence on physiological processes and on tumour progression: ECM properties (composition, stiffness) modulate cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT). For example, EMT is inhibited by laminin-rich environment whereas it is promoted in fibronectin-rich ECM (Chen et al 2013. Differentiation 86, Read more…

A representative hematoxylin and eosin staining of UV-induced skin tumor or skin obtained from SKH-1 mice colonized by S. epidermidis 1457 or MO34, respectively, treated with UV-B for 12 weeks.

Could skin microbiota reduce cancer risk?

Researchers from the Department of Dermatology of the University of California have a commensal strain of Staphylococcus epidermidis that protects against skin neoplasia. This strain produces 6-N-hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. Mice colonized with this strain have a reduced incidence of ultraviolet-induced tumors compared to control mice (colonized with Read more…

New application for HCS

Non-invasive cancer- diagnosis: a new application for HCS HCS was first used in pharmaceutical industry to develop a new way to find new drugs. But this technology is extended since few years in other domains, as diagnosis! source: http://www.int.laborundmore.de/news/694729/A-new-application-for-microscopy.html

HCS to find new metastasis genes

Using automated high content screening and sophisticated computational modeling, the researchers’ screening and analysis of tens of millions of genetically manipulated cells helped them identify more than a dozen genes that influence cell shape. To go more in details of this article, follow this link.