Poster – (ECM 2022) Development of innovative hiPSC-based model including an innovative 3D modified hyaluronic acid hydroscaffold for phenotypic screening

We previously showed that human pluripotent stem cells (hiPSCs) provide a suitable model to studymetabolic diseases upon hepatocyte-like cell (HLC) differentiation. With a non-invasive approach, hiPSCs can be generated from urine samples of patients and HLCs have been used to model cholesterol metabolism regulation, by the study of LDLR- and Read more…

[job position] Ingénieur / Ingénieure en techniques biologiques – Biotechnology Engineer (F/M)

L’ingénieur(e) d’étude mettra au point des méthodes expérimentales permettant de développer un modèle tri-dimensionelle de tumeurs colorectales et de prostate avec la technologie Biomimesys développée par HCS Pharma. La technologie de culture BIOMIMESYS® 3D reproduit fidèlement le microenvironnement naturel des cellules d’un organe cible. Il est attendu un soutien conceptuel Read more…

Extracellular Matrix Modifications in Lung Cancer Initiation, Progression and Propagation

The Extracellular Matrix (ECM) is a major component of all the organs. This dynamic structure is involved not only in cell adhesion, but also in physiological processes, including cell differentiation, migration, and maturation, tissue homeostasis, biochemical signal retention and mediation, and growth factors’ retention. Moreover, the ECM can be abnormally Read more…

Extracellular matrix modifications are involved in cancer initiation, progression and propagation

The extracellular matrix (ECM) is the non-cellular component of tissue. Its is mainly composed of structural and adhesion molecules, such as hyaluronic acid, collagene, proteoglycans, fibronectin, elastin, although its specific composition and structure vary between different tissues. It is a dynamic structure, which is involved not only in the cell Read more…

Importance of the liver extracellular matrix in the development of NASH/ASH

The extracellular matrix (ECM) is a non-cellular component of tissues and organs. It is mainly composed of structural elements (proteoglycans collagens, elastin) and cell adhesion proteins such as fibronectin and laminins. The ECM forms a complex structure with physical properties (elasticity, tensile and compression strength), which provides physical support for Read more…

Robin and Orégane join us to develop a microfluidic system for mechanical sollicitation of cancer spheroids

As part of their engineering studies at ISEN Lille for a master’s degree specialized in Bionanotechnologies, Robin and Orégane arrived in HCS Pharma in May 2021 for a 4-month internship. Their work in HCS Pharma follows a student project during which they designed and computationally simulated a microfluidic device capable Read more…

Our next webinar with Molecular Devices : A physiologically-relevant 3D ECM for in vitro oncology research and intelligent high-content imaging of 3D models

We are very happy to invite you to our next webinar about 3D cellular cancer models and our BIOMIMESYS® Oncology matrix which allows cancer cells to be cultured in a tumor-like environment, with the possibility to tune the composition and stiffness of the matrix. We will also share our best Read more…

Reticulated hyaluronan hydrogels: a model for examining cancer cell invasion in 3D

Abstract The extracellular polysaccharide hyaluronan (HA) controls cell migration, differentiation and proliferation, and contributes to the invasiveness of human cancers. The roles of HA cell surface receptors and hyaluronidases (HAses) in this process are still controversial. In order to investigate their involvement in cancer pathogenesis, we developed a reticulated HA Read more…