A representative hematoxylin and eosin staining of UV-induced skin tumor or skin obtained from SKH-1 mice colonized by S. epidermidis 1457 or MO34, respectively, treated with UV-B for 12 weeks.

We update our services in dermocosmetology for Skin Pigmentation and Oxidative Stress

Summer is alway a good time to improve our services. Then we are very happy to introduce our updated Skin Pigmentation and Oxidative Stress services. Pigmentation is particularly regulated  at  the  cellular  level  by  melanocytes synthesizing  melanin  within  melanosomes,  which  can be  produced  in  varying  sizes,  numbers,  and  densities. In order to evaluate Read more…

Applications for 3D in vitro models with BIOMIMESYS® Adipose Tissue and preview of BIOMIMESYS® Skin

3D cell culture systems have recently emerged as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). In this webinar we will focus on BIOMIMESYS® Adipose Tissue and on the ongoing development of Read more…

Skin microbiota protects their host from oxidative stress through secreted antioxidant RoxP

Many skin diseases, including psoriasis and basal cell carcinoma, are associated with microbial dysbiosis characterized by reduced C. acnes prevalence. C. acnes is a facultative anaerobic bacterium that is frequently found on the human skin. This bacterium is both an opportunistic pathogen and a commensal organism. Indeed, most individuals are Read more…

The human skin microbiota could promote wound healing

Skin commensals are crucial in the maintenance of the epithelial barrier function, regulation of the host immune system, and prevent invasion of other pathogenic microbes.        In this article, published in September 2018, Burmeister et al show that Staphlylococcus, Streptococcus, Pseudomonas, Corynebacterium, and anaerobes have both beneficial and harmful effects depending Read more…

We will attend the “Journées Européenes de Dermocosmétologie” (Lyon, France) the 31th January and 1st February !

The European Center of Dermocosmetology is a french professional association dedicated to the promotion of a high level of education in cosmetology and dermatology. This year, the “Journées Européenes de Dermocosmétologie” will focus on the “intercellular dialogue in the cutaneous tissue: what perspectives in dermocosmetology targeted on weakened skins?” We Read more…

An explanation of assymetric distribution of melanin in the epidermis !

The skin performs important function, including sun protection. Melanin distribution in the epidermis plays a role in photoprotection. Solar radiations induced epidermal DNA damages, mostly in the basal layer, and is an established caused of keratinocytes cancers. Melanin distribution in human epidermis is essentialy located in the basal layer. However, Read more…

Poster – In vitro dermocosmetology : high content analysis approach using human primary keratinocytes and fibroblasts

Cell biology is part of the R&D activity in dermocosmetology, as providers of active extracts or pure compounds have to demonstrate their efficacy and safety. At HCS Pharma, we are developing new dermocosmetology assays on relevant cellular models, like human primary keratinocytes and human primary fibroblasts, using our automated platform and high content analysis system.