Hyaluronic acid (HA) is a linear polymer in which a simple disaccharide is repeated thousands of time, thereby creating a huge hydrophilic molecule that confers a large volume of hydration and contributes to the turgor and flexibility of healthy skin. HA is dynamically produced by most skin cells, not only Read more…
As part of their engineering studies at ISEN Lille for a master’s degree specialized in Bionanotechnologies, Robin and Orégane arrived in HCS Pharma in May 2021 for a 4-month internship. Their work in HCS Pharma follows a student project during which they designed and computationally simulated a microfluidic device capable Read more…
Soria et al. has published this year an interesting study about the modification leading by synucleopathy on the nanoscale organization and diffusivity of the extracellular space, through hyaluronan remodeling. Indeed the extracellular space (ECS), composed by the interstitial fluid and the extracellular matrix (ECM), plays several roles in health and Read more…
In the continuity of our scientific reviews about the important roles of Hyaluronic Acid (HA) in extracellular matrix (ECM) and cell behavior, we herein present this recent review describing the structure – function relationship of HA. As an important polysaccharide of ECM, HA plays an important role in cell and Read more…
Stroke is the second leading cause of death worldwide and the most common cause of disability in adults. Ischemic stroke represents 80% of the cases. They cause oxygen and glucose deficit in the brain, leading to necrosis, edema formation, inflammation and apoptosis. Endogenous repair mechanisms, like cerebral plasticity, limit ischemia-linked Read more…
We will be present this week and next week in Rotterdam, to talk about 3D cell culture and the importance of the microenvironnement in the relevance of in vitro models. As you known, to mimic human tissues, several parameters need to be taken into account: the target cells, nutrient intake Read more…
The extracellular matrix (ECM) is a three-dimensional macromolecular network composed of structural proteins (collagens, elastin), adhesion/signalling proteins (fibronectin, laminins), different proteoglycans, glycoproteins and glycosaminoglycans (GAGs). GAGs are structurally complex, but their structure is simply made up of repeating disaccharide building blocks composed of alternating uronic acid and hexosamine units. GAGs Read more…
Next week HCS Pharma will be present at SFBMEc Reims (15th-17th May). We will present a poster about the influence of BIOMIMESYS® hydroscaffold composition and stiffness on the 3D culture of breast cancer cells. The poster will be avalaible next week, but if you want it before, you can contact Read more…
BIOMIMESYS® Oncology is mostly composed of hyaluronic acid (HA), biofunctionnalized with undenaturated collagen I. HA, by interacting with its binding proteins (CD44, RHAMM, ICAM-1), is an active participant in inflammatory, angiogenic, fibrotic and cancer-promoting processes (Figure 1). We are currently looking at the effect of different elastic moduli of BIOMIMESYS® Read more…
Cells have diverse circuitry to sense and respond to extrinsic metabolic signals. Extracellular matrix (ECM) reorganization which is central to both tissue expansion and regeneration. ECM remodeling is also a signature of pathological processes, such as tumorigenesis. In this study from Sullivan et al., they show that increased migration in Read more…
Abstract The lack of relevant in vitro models for adipose tissue makes necessary the development of a more physiological environment providing spatial and chemical cues for the effective maturation of adipocytes. We developed a biofunctionalized hydrogel with components of adipose extracellular matrix: collagen I, collagen VI, and the cell binding Read more…
BIOMIMESYS® Technology is a biomimetic hydrogel based on biofunctionalized hyaluronic acid with extracellular matrix components