Chez HCS Pharma, nous sommes ravis de partager avec vous les avancées significatives que nous avons réalisées dans nos projets de recherche et développement. Avant de commencer, nous tenons à remercier “La Gazette du Laboratoire” pour leur soutien continu et leur couverture détaillée de nos efforts. Notre entreprise, basée à Read more…
After obtaining this Master’s degree in Biology and Health Science at Lille University in 2022, Nathan Laneret has just begun a PhD thesis under the supervision of Pr. RA Toillon and Dr. Nathalie Maubon thanks to ANRT fundings (CIFRE). Through this collaboration between the Cellular Plasticity and Cancer team from Canther Lab Read more…
Next week we will have the pleasure to attend FOOD INGREDIENTS EUROPE & HEALTH INGREDIENTS EUROPE (FIE/HIE), which will take place in Paris, Porte de Versailles. Food ingredients Europe has been uniting the world’s leading food & beverage suppliers, buyers, R&D experts and production specialists for over 35 years. Originally Read more…
The first edition of OncoLille Days congress took place from November 2th to 4th, 2022 in Lille. All 3 days were very rich in interesting presentations about interdisciplinary research in oncology, including biology, mathematics, human sciences, etc. Our project leader Véronique De Conto was pleased to present her poster about Read more…
We are glad to announce the arrival of Gaspard in our team! Gaspard Delpouve obtained his Diploma of Advanced Technician in Biotechnologies in Lille in 2018, and in 2019 he passed a Bachelor’s degree in health biotechnologies at the University of Nantes. During his studies he completed several internships in Read more…
Next month, we will have the pleasure to participate in the 23rd EUSAAT (EUropean Society for Alternative to Animal Testing) congress, which will take place in Linz (Austria) on the 26th-28th of September. We have proposed an abstract about how we use 3D in vitro cell culture models for recapitulating Read more…
To treat brain disease is a challeging purpose, since the brain is protected by a barrier made by of tightly-joined endothelial cells of the cerebral microvessels, called the blood–brain barrier (BBB). To improve this route to reach the central nervous system, several strategies have been developed. Among them, researchers try Read more…
Increased ExtraCellular Matrix (ECM) stiffness is a common process in many cancers (Pickup et al, 2014). This process influences the behaviour of cancer cells in the tumour microenvironment. The accumulation of ECM in the stroma is mainly due to a high production of ECM molecules by TGF-β(Transforming Growth Factor-beta) -stimulated Read more…
High Throughput Screening (HTS) has been developed in the 80s, in the context of the automation and miniaturization of techniques for biological assays. Thanks to multiwell plates (96, 384, 1536, or 3456 wells) handled on a platform with robotic arms and automated pipetting systems, it allows to test hundreds of Read more…
In the context of NanoStem Project, a Marie-Curie Innovative Training Network project funded by the European Union’s Horizon 2020, and in collaboration with HCS Pharma, Elisa L.J. Moya defensed successfully her PhD the 15th December 2021 in Université d’Artois (Lens, France) about the miniaturization and automation of a well-established human Read more…
In 2020, Nia et al. published in the journal Science a review entitled ‘Physical traits of cancer‘. In this article, the authors proposed 4 distinct physical traits of cancer linked to the biomechanical abnormalities observed in tumoral tissues : an enhanced solid stress (compression and tension), i.e. the mechanical forces Read more…
2D cell culture has been used for more than 100 years now, to keep cells outside of their original organism and to use them for different purposes. It is still widely used in research and early steps of the drug discovery process, and has allowed a bunch of discoveries so Read more…
We were glad to welcome Roberta Bilardo for a 2 month-secondment in HCS Pharma in the frame of Nanostem project (Developing NANOmaterials for neural STEM cells drug delivery). She is working as a Marie Curie Fellow Early Stage Researcher in Prof Resmini’s research group at the School of Biological and Read more…
Cultivated meat is meat produced from cells cultures, and it appears as a promising alternative to traditional meat derived from animals. Sometimes known as clean meat, cultured meat or in vitro meat, such cells are cultured in a customizable and controlled platform. The manipulation, enhancement as well as adaptation of Read more…
When Tuesday, March 23, 2021 – 1PM (CET) / 8PM (CST) / 9PM (JST) / 7AM (EST) Thursday, March 25, 2021 – 9AM (CET) / 4PM (CST) / 5PM (JST) / 3AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently emerged as promising tools Read more…
When Tuesday, February 23, 2021 – 1PM (CET) / 8PM (CST) / 9PM (JST) / 7AM (EST) Thursday, February 25, 2021 – 9AM (CET) / 4PM (CST) / 5PM (JST) / 3AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently as promising Read more…
As many companies in France and in the world, the COVID-19 pandemic deeply affects our activities. For safety reasons, most of our work is now done remotely but we maintain essential activity in laboratories to take care of our cells and try to finish our ongoing customer studies. The situation Read more…
Last week, our study director Elodie was in Rennes to participate in NutrEvent! We had a booth there, under NSL Clubster pavilion (Lille Northern France Health and Nutrition clubster). It was a pleasure for her to present our activities in imaging and our 3D cell culture products to the visitors! Read more…
BIOMIMESYS® Oncology is mostly composed of hyaluronic acid (HA), biofunctionnalized with undenaturated collagen I. HA, by interacting with its binding proteins (CD44, RHAMM, ICAM-1), is an active participant in inflammatory, angiogenic, fibrotic and cancer-promoting processes (Figure 1). We are currently looking at the effect of different elastic moduli of BIOMIMESYS® Read more…
Originally, cosmetics were tested on animals, but since a couple of year’s manufacturer have tried to avoid this test to match the new regulation on animal testing. Today, most of the test will be conducted on human skin or eye tissue or even human skin culture. In order to find Read more…
Veronique obtained an engineering degree from the Toulouse agronomic school (ENSAT) in 2017, with a specialization in biotechnology at AgroParisTech. During her studies, she worked on the cholinergic receptors structure of the parasitic nematode Trichinella spiralis during a 3-month internship in the French Agency for Food, Environmental and Occupational Health Read more…
For ethical and cost-related reasons, use of animals for the assessment of mode of action, metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in research and industrial applications. Physiologically based pharmacokinetic (PBPK2) modeling is the most potent in silico tool used for extrapolation of pharmacokinetic parameters to Read more…
Cell biology is part of the R&D activity in dermocosmetology, as providers of active extracts or pure compounds have to demonstrate their efficacy and safety. At HCS Pharma, we are developing new dermocosmetology assays on relevant cellular models, like human primary keratinocytes and human primary fibroblasts, using our automated platform and high content analysis system.