To treat brain disease is a challeging purpose, since the brain is protected by a barrier made by of tightly-joined endothelial cells of the cerebral microvessels, called the blood–brain barrier (BBB). To improve this route to reach the central nervous system, several strategies have been developed. Among them, researchers try Read more…
Increased ExtraCellular Matrix (ECM) stiffness is a common process in many cancers (Pickup et al, 2014). This process influences the behaviour of cancer cells in the tumour microenvironment. The accumulation of ECM in the stroma is mainly due to a high production of ECM molecules by TGF-β(Transforming Growth Factor-beta) -stimulated Read more…
High Throughput Screening (HTS) has been developed in the 80s, in the context of the automation and miniaturization of techniques for biological assays. Thanks to multiwell plates (96, 384, 1536, or 3456 wells) handled on a platform with robotic arms and automated pipetting systems, it allows to test hundreds of Read more…
In the context of NanoStem Project, a Marie-Curie Innovative Training Network project funded by the European Union’s Horizon 2020, and in collaboration with HCS Pharma, Elisa L.J. Moya defensed successfully her PhD the 15th December 2021 in Université d’Artois (Lens, France) about the miniaturization and automation of a well-established human Read more…
In 2020, Nia et al. published in the journal Science a review entitled ‘Physical traits of cancer‘. In this article, the authors proposed 4 distinct physical traits of cancer linked to the biomechanical abnormalities observed in tumoral tissues : an enhanced solid stress (compression and tension), i.e. the mechanical forces Read more…
2D cell culture has been used for more than 100 years now, to keep cells outside of their original organism and to use them for different purposes. It is still widely used in research and early steps of the drug discovery process, and has allowed a bunch of discoveries so Read more…
We were glad to welcome Roberta Bilardo for a 2 month-secondment in HCS Pharma in the frame of Nanostem project (Developing NANOmaterials for neural STEM cells drug delivery). She is working as a Marie Curie Fellow Early Stage Researcher in Prof Resmini’s research group at the School of Biological and Read more…
Cultivated meat is meat produced from cells cultures, and it appears as a promising alternative to traditional meat derived from animals. Sometimes known as clean meat, cultured meat or in vitro meat, such cells are cultured in a customizable and controlled platform. The manipulation, enhancement as well as adaptation of Read more…
When Tuesday, March 23, 2021 – 1PM (CET) / 8PM (CST) / 9PM (JST) / 7AM (EST) Thursday, March 25, 2021 – 9AM (CET) / 4PM (CST) / 5PM (JST) / 3AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently emerged as promising tools Read more…
When Tuesday, February 23, 2021 – 1PM (CET) / 8PM (CST) / 9PM (JST) / 7AM (EST) Thursday, February 25, 2021 – 9AM (CET) / 4PM (CST) / 5PM (JST) / 3AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently as promising Read more…
The job offer in english is available here Dans le cadre de notre développement, nous recrutons un chef de projet (H/F) en oncologie pour mener les projets de R&D et les études clients dans le domaine. L’accent sera mis en particulier sur le microenvironnement tumoral, en travaillant sur l’aspect matrice Read more…
L’offre d’emploi en français est disponible ici As part of our development, we are looking for an oncology project manager (M/F) to lead R&D projects and client studies in the field. Particular emphasis will be given to the tumor microenvironment, working on the extracellular matrix aspect using BIOMIMESYS®, our 3D Read more…
As many companies in France and in the world, the COVID-19 pandemic deeply affects our activities. For safety reasons, most of our work is now done remotely but we maintain essential activity in laboratories to take care of our cells and try to finish our ongoing customer studies. The situation Read more…
Last week, our study director Elodie was in Rennes to participate in NutrEvent! We had a booth there, under NSL Clubster pavilion (Lille Northern France Health and Nutrition clubster). It was a pleasure for her to present our activities in imaging and our 3D cell culture products to the visitors! Read more…
BIOMIMESYS® Oncology is mostly composed of hyaluronic acid (HA), biofunctionnalized with undenaturated collagen I. HA, by interacting with its binding proteins (CD44, RHAMM, ICAM-1), is an active participant in inflammatory, angiogenic, fibrotic and cancer-promoting processes (Figure 1). We are currently looking at the effect of different elastic moduli of BIOMIMESYS® Read more…
Originally, cosmetics were tested on animals, but since a couple of year’s manufacturer have tried to avoid this test to match the new regulation on animal testing. Today, most of the test will be conducted on human skin or eye tissue or even human skin culture. In order to find Read more…
Veronique obtained an engineering degree from the Toulouse agronomic school (ENSAT) in 2017, with a specialization in biotechnology at AgroParisTech. During her studies, she worked on the cholinergic receptors structure of the parasitic nematode Trichinella spiralis during a 3-month internship in the French Agency for Food, Environmental and Occupational Health Read more…
For ethical and cost-related reasons, use of animals for the assessment of mode of action, metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in research and industrial applications. Physiologically based pharmacokinetic (PBPK2) modeling is the most potent in silico tool used for extrapolation of pharmacokinetic parameters to Read more…
Cell biology is part of the R&D activity in dermocosmetology, as providers of active extracts or pure compounds have to demonstrate their efficacy and safety. At HCS Pharma, we are developing new dermocosmetology assays on relevant cellular models, like human primary keratinocytes and human primary fibroblasts, using our automated platform and high content analysis system.
A very interesting talk will be done by Marc Pissavini in next Cosmeticdays (1st and 2nd December in Marseille).
ESTIV conference, named In Vitro Toxicology for Human Safety Assessment, takes place this week in Juan-les-Pins. This congress brings together a lot of toxicologists, from public and private, to discuss the last development of predictive in vitro models in safety testing, as 3D models, organ-on-a-chip, bioprint organs. To learn more and to exchange on these Read more…