We are pleased to welcome Natacha Perrin in our laboratory for a 6-month internship. Natacha is currently in last year of engineering school in Polytech Clermont. This year, in parallel of her initial formation, she also did a double degree in pharmacy. During her studies, she had the opportunity to Read more…
Yesterday, the 11th of April, was the World Parkinson’s Day. On this occasion, HCS pharma would like to inform you about this disease and its work for new drug discovery. What is Parkinson’s disease? It is the second most common neurodegenerative disease after Alzheimer’s disease. It is attributed to a Read more…
About 90% of drug candidates fail in clinical trials, for efficacy- and toxicity-related reasons, which often involve the Central Nervous System (CNS). This high failure rate highlights a lack of relevance in experimental models used upstream, including human in vitro models. Indeed, they do not take into account the complexity Read more…
It is our pleasure to announce that the article of our PhD Student Véronique De Conto has been published in Toxicology in vitro journal. This work comes from a collaboration between HCS Pharma and Inserm Unit “Degenerative & vascular cognitive disorders”. This article highlight the importance to consider carefully the Read more…
In the brain, we have about 100 billion of neurons but they represent only 10 to 50% of the total cells (von Bartheld et al., 2016). Indeed, glial cells, including astrocytes, oligodendrocytes and microglia are also essential to the physiological functions of the brain. Parkinson’s Disease (PD) is the secondary Read more…
The pharmaceutical industries face to a major issue, which is a very high failure rate in drug discovery, with 90% of failure in clinical trials. The central nervous system is particularly concerned, with an involvement in 30% of safety failure in clinical trials, but only in 7% in preclinical trials Read more…
Soria et al. has published this year an interesting study about the modification leading by synucleopathy on the nanoscale organization and diffusivity of the extracellular space, through hyaluronan remodeling. Indeed the extracellular space (ECS), composed by the interstitial fluid and the extracellular matrix (ECM), plays several roles in health and Read more…
Parkinson’s disease affects more than 6 million people worldwide. This neurodegenerative disease is characterized by the death of dopaminergic neurons in the substantia nigra pars compacta, with intracellular accumulation of alpha-synuclein aggregates known as Lewi bodies. This neuronal loss leads to a decrease in the neurotransmitter dopamine that cause mainly Read more…
There are 90% of failure in clinical trials, mainly due to safety and efficiency issues. In particular, the central nervous system is involved in 34% of failure in clinical trials, but only in 7% of failure in preclinical trials (Cook et al., 2014). That points a lack of relevance in Read more…
The human brain contains approximately 86 billon neurons of different types, distributed and organized in different areas ; their functions vary according to the neuron type and its localization within the brain. However, the neuronal function also depends on its microenvironment, which is composed of the extracellular matrix (ECM), and Read more…