Cell hyaluronan

Breakdown of the extracellular matrix (ECM) promotes increased cell migration via upregulation of glycolysis

Cells have diverse circuitry to sense and respond to extrinsic metabolic signals. Extracellular matrix (ECM) reorganization which is central to both tissue expansion and regeneration. ECM remodeling is also a signature of pathological processes, such as tumorigenesis. In this study from Sullivan et al., they show that increased migration in Read more…