Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. This connective tissue which is the dermal extracellular matrix (ECM) produced, organized, and maintained by dermal fibroblasts and confers strength and resiliency to skin. In young skin, fibroblasts produce and adhere to the dermal Read more…
Primary keratinocytes were stained to reveal nuclei in blue, cellular keratin 14 in green and actin filaments in red. This image has been taken with the fluorescence microscope from Molecular Devices. See our brochure to discover our services in dermocosmetology. For more information about our models, please feel free to Read more…
Hyaluronic acid (HA) is a linear polymer in which a simple disaccharide is repeated thousands of time, thereby creating a huge hydrophilic molecule that confers a large volume of hydration and contributes to the turgor and flexibility of healthy skin. HA is dynamically produced by most skin cells, not only Read more…
Skin redness is a sign of cutaneous inflammation which can lead to major skin disorders, such as dermatitis (eczema), which affects 10% of the population and by this way, represents the most common skin disease. The mechanism of skin inflammation is complex and still not fully clarified. When the skin Read more…
Summer is alway a good time to improve our services. Then we are very happy to introduce our updated Skin Pigmentation and Oxidative Stress services. Pigmentation is particularly regulated at the cellular level by melanocytes synthesizing melanin within melanosomes, which can be produced in varying sizes, numbers, and densities. In order to evaluate Read more…
Since the beginning of this year we have created four webinars to present our BIOMIMESYS® technology and practical uses. We have chosen to focus on the scientific side of our innovation by presenting results in drug discovery or dermocosmetology domains. Theses four webinars are available on our support page (with many Read more…
3D cell culture systems have recently emerged as promising tools for reproducing the cellular environment and the organization of tissues/organs, where cells are connected to each other and to the surrounding extracellular matrix (ECM). In this webinar we will focus on BIOMIMESYS® Adipose Tissue and on the ongoing development of Read more…
When Tuesday, April 20, 2021 – 1PM (CET) / 8PM (CST) / 9PM (JST) / 7AM (EST) Thursday, April 22, 2021 – 9AM (CET) / 4PM (CST) / 5PM (JST) / 3AM (EST) Where Online, using zoom.us and live on Youtube What 3D cell culture systems have recently emerged as promising tools Read more…
The extracellular components of the skin can be divided into fiber-forming structural molecules, nonfiber-forming structural molecules, and “matricellular proteins”. Optimal quantities of different matrix components and their delicate interactions are necessary to maintain normal physiologic properties of the skin. Fiber-forming molecules provide a structure to the ECM by creating a Read more…
The founding congress of the french STCM (Société de Toxicologie Cellulaire et Moléculaire) will take place in Paris at the end of this week (13th-14th June, 2019). The theme of this meeting will be “Toxicology towards the 3rd dimension“. We are looking forward to attending this congress, and to becoming Read more…
Even if microbiota-relateds treatments are quite recent in the therapeutical field, at least 2,400 clinical trials were launched in 2018! Gut, skin and oncology microbiota will be definitively be the hot topic in the next 10 years. Of course, we are heavily working in the field, with a focus on Read more…
After a bachelor of science in biology, Solenne has been graduated with a two-year diploma “DUT Génie Biologique”, specialized in biological and biochemistry analysis. Afterwards, she wenty on with a professional bachelor’s degree dealing with the development of cosmetic and health products at Université Bretagne Sud in Vannes, where she Read more…
Jean-Baptise obtained his Master’s degree in Cellular and Molecular Biology at Paris-Sorbonne University in 2018 after a six-month internship with us. He focused on the development of a human microbiota model in collaboration with the Pharmacology Lab of University of Rennes 1 (INSERM U1230). He will keep on working on Read more…
The skin performs important function, including sun protection. Melanin distribution in the epidermis plays a role in photoprotection. Solar radiations induced epidermal DNA damages, mostly in the basal layer, and is an established caused of keratinocytes cancers. Melanin distribution in human epidermis is essentialy located in the basal layer. However, Read more…
Melanoma is a type of skin cancer that develops from cells called melanocytes, is one of the fastest-growing and deadliest cancer in the world. It usually caused by DNA damage resulting from exposure to ultraviolet (UV) light from the sun. P. acnes is a ubiquitous gram-positive anaerobic bacterium present in Read more…
Researchers from the Department of Dermatology of the University of California have a commensal strain of Staphylococcus epidermidis that protects against skin neoplasia. This strain produces 6-N-hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. Mice colonized with this strain have a reduced incidence of ultraviolet-induced tumors compared to control mice (colonized with Read more…
The creation of a double strand break (DSB) is accompanied by the phosphorylation of histone H2AX. The measurement of serine 139 phosphorylated histone H2AX (γH2AX) is reported to be a marker of interest to identify potential genotoxic activity.
3dfab in Lyon reproduces the different layers of the skin (epidermis, dermis) with 3D bioprinting technology.
