Biomimesys
On the importance of extracellular matrix of the skin for efficient 3D cell culture models
The extracellular components of the skin can be divided into fiber-forming structural molecules, nonfiber-forming structural molecules, and “matricellular proteins”. Optimal quantities of different matrix components and their delicate interactions are necessary to maintain normal physiologic properties of the skin. Fiber-forming molecules provide a structure to the ECM by creating a Read more…
Biomimesys
Founding congress of STCM association in Paris this week
The founding congress of the french STCM (Société de Toxicologie Cellulaire et Moléculaire) will take place in Paris at the end of this week (13th-14th June, 2019). The theme of this meeting will be “Toxicology towards the 3rd dimension“. We are looking forward to attending this congress, and to becoming Read more…
HCS, HCA & Biology
Microbiota companies unite to push for EU regulation reform
Even if microbiota-relateds treatments are quite recent in the therapeutical field, at least 2,400 clinical trials were launched in 2018! Gut, skin and oncology microbiota will be definitively be the hot topic in the next 10 years. Of course, we are heavily working in the field, with a focus on Read more…
News
Solenne joins us for an internship in dermocosmetology
After a bachelor of science in biology, Solenne has been graduated with a two-year diploma “DUT Génie Biologique”, specialized in biological and biochemistry analysis. Afterwards, she wenty on with a professional bachelor’s degree dealing with the development of cosmetic and health products at Université Bretagne Sud in Vannes, where she Read more…
News
Jean-Baptiste joins our team as PhD student on an in vitro skin microbiota model topic
Jean-Baptise obtained his Master’s degree in Cellular and Molecular Biology at Paris-Sorbonne University in 2018 after a six-month internship with us. He focused on the development of a human microbiota model in collaboration with the Pharmacology Lab of University of Rennes 1 (INSERM U1230). He will keep on working on Read more…
HCS, HCA & Biology
An explanation of assymetric distribution of melanin in the epidermis !
The skin performs important function, including sun protection. Melanin distribution in the epidermis plays a role in photoprotection. Solar radiations induced epidermal DNA damages, mostly in the basal layer, and is an established caused of keratinocytes cancers. Melanin distribution in human epidermis is essentialy located in the basal layer. However, Read more…
HCS, HCA & Biology
P. acnes inhibits human melanocytes survival after UVB radiation which could prevent melanoma-genesis causes by DNA damage
Melanoma is a type of skin cancer that develops from cells called melanocytes, is one of the fastest-growing and deadliest cancer in the world. It usually caused by DNA damage resulting from exposure to ultraviolet (UV) light from the sun. P. acnes is a ubiquitous gram-positive anaerobic bacterium present in Read more…
HCS, HCA & Biology
Could skin microbiota reduce cancer risk?
Researchers from the Department of Dermatology of the University of California have a commensal strain of Staphylococcus epidermidis that protects against skin neoplasia. This strain produces 6-N-hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. Mice colonized with this strain have a reduced incidence of ultraviolet-induced tumors compared to control mice (colonized with Read more…
Posters
Poster – Development of double stand break assessment assay with HCS by using the HepG2 cell line and evaluation with primary skin cell (NHEK)
The creation of a double strand break (DSB) is accompanied by the phosphorylation of histone H2AX. The measurement of serine 139 phosphorylated histone H2AX (γH2AX) is reported to be a marker of interest to identify potential genotoxic activity.
HCS, HCA & Biology
Skin reconstitution by 3D bioprinting
3dfab in Lyon reproduces the different layers of the skin (epidermis, dermis) with 3D bioprinting technology.