It is well established that the extracellular matrix (ECM) plays a central role in cell homeostasis and cell adhesion by providing support, promoting cell-to-cell communication and differentiation (or dedifferentiation and tumoral progression when the ECM is modified). The composition but also the stiffness and elasticity of the ECM have important implications in cell migration, gene expression and differentiation. Components of the ECM are produced intracellularly by resident cells and secreted into the ECM via exocytosis. The ECM includes the interstitial matrix and the basement membrane. The ECM is formed by gels of polysaccharides and fibrous proteins.

ECM is a solid scaffold made by polymerization of GAG, where adhesion proteins were greffed, entangled by collagen polymer.

In ECM, Hyaluronic Acid (HA) is a key player which has different properties. This GAG has the properties to polymerise and thus made a solid scaffold which keeps the structure of the tissue. Furthermore, this component has different functions that binds to water molecules which allow water adsorption and that selectively bind different growth factor.

HA acts as an environmental cue that regulates cell behavior during embryonic development, healing processes, inflammation, and tumor development. It interacts with a transmembrane receptor, CD44.

BIOMIMESYS® technology

The fact that we have found a process to used hyaluronic acid as biopolymer to synthesis our 3D cell culture system allows us to keep all properties of hyaluronic acid and thus to reproduce at the best the ECM with all biological properties (same structure, cell adhesion, water stockage, signal reservoir …).

Our BIOMIMESYS® technology is the only one on the market with these 2 properties, which are to be solid and to bind to water molecules and thus to allow water adsorption. It is because of these 2 properties, we called this 3D system : hydroscaffold.

To mimic the ECM, we need to know the physicochemical properties (mechanical & composition) in normal and pathological organs.

Mechanical properties : elastic modulus of organs’ ECM

Variations in tissue stiffness from “Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer”

Composition of ECM

During different pathologies (like liver fibrosis or cancer), the secretion of collagen and GAGs is modified, therefore modifying the stiffness of the environment

Modification of the ECM of the liver during the different steps of liver disease : steatosis, NASH, fibrosis, cirrhosis
Disruption of ECM during tumor progression

Advantages of BIOMIMESYS® products

Long-term maintenance of cellular functionalities : Compared to 2D, BIOMIMESYS® helps you to get cells fully functional more than one month

In vitro assays as in real boby : Composition and rigidity of BIOMIMESYS® products are similar to the real organ to help you to test your compounds in real situation. And, for each organ (healthy or pathologic), we can develop a specific hydroscaffold ECM, by fine tuning its elastic modulus and its composition.

Stability of the composition : The production method ensures perfect product composition stability

Take it, use it in the hour : BIOMIMESYS® technology is really easy to use, as a classical 2D plates. We provide you video tutorials, process and support to help you.

Any questions? Please contact us

Grégory MAUBON

Grégory MAUBON is Chief Data Officer and digital coordinator at HCS Pharma, a biotech startup focused in high content screening and complex diseases. He manages IT missions and leads digital usages linked to company needs. He is also a Augmented Reality Evangelist (presenter and lecturer) since 2008, where he created and founded in 2010 RA'pro (the augmented reality promotion association). He helped many companies (in several domains) to define precisely their augmented reality needs and supported them in the implementation.


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