Distinguishing aneugenic (chromosomes loss) from clastogenic effects (DNA damages) is essential to assess genotoxic properties of compounds.
In order to help you taking the right decisions for your compounds, we developed a multiplex assay in order to discriminate aneugenic from clastogenic and cytotoxic effects of your compounds in one single assay !
Based of the combined assessment of micronuclei and the phosphorylation of histone H2AX and H3, our assay allows to distinguish between clastogenic and aneugic genotoxic effects after only 24 hours of exposure to your compounds.
This assay is already validated on HepG2 cells with our in-house genotoxicity library. If you want to study other cells lines, including primary or iPS cells, we also propose validation services for this multiplex assay.
By combining the outputs, we propose a fast and cheap assay for your genotoxicity studies!