Prof. Romeo Cecchelli graduated as a physiologist and holds a PhD in Physiology and a ‘Doctorat es sciences’ in Biochemistry from the University of Lille.
He soon became interested in the transport of drugs across the blood-brain barrier and in the early 90’s he set up, at the Pasteur Institute in Lille, an in vitro blood-brain barrier (BBB) model (consisting of a coculture of brain capillary endothelial cells and glial cells). This model has shown a high correlation between in vitro and in vivo permeability for a wide range of molecules. In 1997, he was appointed a full Professor in Cell Biology (Artois University, Lens, France) and was the first vice-president of Artois University in charge of the research from 2005 to 2015. He was involved in several European research programs: he was the coordinator of BBB follow-up (an ECVAM funded study, 2006-2007) and participated in FP6 ACUTOX (2006-2010), FP7 PREDICT IV and EUSTROKE (WP leader: In vitro models of the blood brain barrier, 2010-2013). He contributed to several research contracts with pharmaceutical companies (Servier, Sanofi Astrazeneca, etc.). In 2014, his lab developed a stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells (patent n°WO/2014/203087), showing a very nice correlation with human in vivo data.
David Devos obtained his ‘Doctor of Neurology’ and ‘Doctor of Neuroscience’ degrees from the University of Lille, France. Between 2002 and 2010, he worked as a hospital physician in the Department of Neurology of the Centre Hospitalier Universitaire of Lille, where he is now Professor in Medical Pharmacology (Lille University, INSERM UMR_S1171).
His main research interest is the development of new disease-modifying strategies in neurodegenerative diseases, particularly Parkinson’s disease and amyotrophic lateral sclerosis, but also dementia and cerebellar ataxia.
His research is mainly based upon clinical trials but also includes preclinical, translational and clinical studies in neuropsychopharmacology. He was directly involved in 28 studies including 14 multicentric and 14 as the coordinator (8 in progress), including the European multicentric study, FAIRPARK-II, of Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease (http://fairpark2.eu). He received several prizes, notably the Prize of innovation “From Bench to bed” of Eurasanté in 2015 for the innovative therapeutic strategy of DIVE (Dopamine with intracerebroventricular administration) and the European pharmacology scientific award EACPT for the best scientific work of the two last years in 2013.
Dr. Georg Haase, MD PhD, is a team leader at Institut de Neurosciences de la Timone in Marseille and co-coordinator of research on amyotrophic lateral sclerosis (ALS) at Marseille’s Center of Excellence in Neurodegeneration DHUNE.
Georg Haase has pioneered gene therapy approaches in ALS and investigated neurodegenerative pathways in cellular and and animal models of ALS and related motor neuron diseases. His lab has acquired unique expertise in isolating pure motor neurons by fluorescent-activated cell sorting (FACS) from human iPSc-derived cultures and embryonic mice and in analysing them by flow cytometry.
Karim Si-Tayeb has developed an expertise in human induced pluripotent stem cells (hiPSCs) differentiation and disease modelling. His experience on liver chronic disease acquired during his Ph.D. at the university of Bordeaux, France, and on liver development during his postdoctoral work at the Medical College of Wisconsin (Milwaukee, WI, USA) led him to focus his research on the study of liver metabolic disease. In 2012, he joined Bertrand Cariou’s team at the thorax institute in Nantes (http://www.umr1087.univ-nantes.fr/equipe-iv-dyslipidemies-et-lipotoxicite–1518230.kjsp) to study lipid disorders such as familial hypercholesterolemia and familial hypobetalipoproteinemia. He is currently participating to the RHU CHOPIN (https://rhuchopin.fr/), which aims at decreasing cardiovascular events in hypercholesterolemic patients through precision medicine.
Dominique Collard was born in Cambrai, France in 1958. He received the Eng. Degree from ISEN (Institut Supérieur d’Electronique et du Numérique) in 1980, and the PhD degree from the University of Lille in 1984. Since 1988, he has been with the Centre National de la Recherche Scientifique (CNRS), being alternatively with the Institut d’Electronique, de Microélectronique et de Nanotechnologie (IEMN), Lille, and with the Laboratory for Integrated MicroMechatronic Systems (LIMMS/CNRS-IIS), Tokyo. In Dec. 2011, he became coordinator of EC/FP7 INCOLAB: EUJO-LIMMS aiming to open LIMMS to European partners and first EC laboratory in Japan. He is authors or co-author of more than 300 international publications. Dominique Collard got the CNRS bronze medal in 1992, and was in 2004 Laureate of the French academic palms from Ministry of higher education and research. In June 2014 he was named as Director the SMMiL-E Project (Seeding Micro System in Medecine in Lille: European-Japanese technologies against Cancer) to pull BioMEMS to Cancer research of Lille, France in a project supported by CNRS, IIS/The University of Tokyo, Lille University, Centre Oscar Lambret. From April 2016, back in Lille Dominique Collard is in the coordination the CPER Cancer plan that aims gathering research on physics, human science, biology and clinics for Cancer in a unique place inside the Lille University hospital campus.
SMMiL-E relates to the setting-up and the realization of a comprehensive research program on bioMEMS against Cancer in a sustainable international high-level collaboration. The project synergizes the bio-MEMS research from LIMMS/CNRS-IIS with the research against Cancer performed in Lille area under the SIRIC ONCOLille program. To reach its objectives, SMMiL-E encompasses the transfer in the Hauts de France region of Bio MEMS type micro technologies stemming from LIMMS, The joint research laboratory between the institute of Industrial Sciences, The University of Tokyo and CNRS. The bioMEMS technologies are installed in a platform located in the mere hospital-university area, in order to be in close contact with medical teams with facilitated access to clinical research. The transferred technologies are positioned as a continuation of the advanced technologies of IEMN as an their extension towards biology and medical applications.
Dr. Samuel Meignan is a senior researcher at the « Cell Plasticity and Cancer » Inserm U908 laboratory and the head of the Tumorigenesis and Resistance to Treatment Unit in Oscar Lambret Center (Lille, France).
He holds a Ph.D. in Cellular and Molecular Biology from Lille University for his works on the role of neurotrophins receptors in breast cancer cells phenotype, especially their sensitivity to apoptogenic agents. He joined Inserm U837 for a four years postdoctoral position in Antitumoral Pharmacology. In collaboration with Lille Faculty of Pharmacy and some pharmaceutical industries as Merck KGaA and Pierre Fabre Laboratories, he led evaluations of new antitumor compounds and innovative therapeutic strategies in different cancers as head and neck or pediatric brain tumors. He developed an expertise in drug testing in vitro and in vivo, but also in the understanding of mechanism leading to resistance to treatment. In 2013, Oscar Lambret cancer comprehensive center entrusted him the direction of its basic research unit refocused on deciphering and skirting of mechanisms involved in pediatric gliomas resistance to treatment. Currently, his main project aims to determine the role of H3.3K27M mutation in the low response to chemo and radiotherapy of Diffuse Intrinsic Pontine Gliomas.
He is a scientific expert for French Society of Fight Against Cancer and Leukemias of Children and Adolescents, and a referee for Journal of Applied Oral Science. He supervised a number of students including three Ph.D. and numerous master students. He also teaches master courses for “Biology & Health” at the Faculty of Medicine at Lille University.