BIOMIMESYS® Adipose tissue

Regulation of lipid accumulation : application with BIOMIMESYS® Adipose tissue

Retinoic acid and Caffeine are reference molecules known for their inhibitory activity on lipogenesis. Retinoic acid, a derivative of vitamin A, inhibits adipogenesis by blocking adipogenic factors such as PPARγ2 and C / EBPα, via the Retinoic acid receptor (RAR) ligand (1). Caffeine, a non-selective adenosine antagonist receptor, is used Read more…

Simplifying 3d cell culture generation for high content screening with BIOMIMESYS® and the Viaflo 96-384 (with Integra Biosciences)

Growing interest in phenotypic screening, together with evidence that the drug response of cells grown in three-dimensional (3D) structures more closely resembles in vivo activity, has made high throughput, 3D fluorescence imaging an attractive screening option for drug discovery. However, creating 3D spheroids compatible with high content screening can be Read more…