The intestinal epithelium represents an essential functional barrier for the organism. Characterized by a cell monolayer, it is mainly composed of polarized absorbing cells, the enterocytes. The intestinal epithelium is a dynamic interface between the external environment and the intestinal tissues. This permeable barrier plays a major role in the regulation of solute and fluid exchange, with direct consequences on nutrient absorption and transport. As such a dynamic interface, the intestinal epithelium is prone to oxidative damage induced by luminal oxidants, and which participates in digestive disorders appearance. HCS Pharma has developped tests to assess actives efficacy against it.
In vitro ROS assessment : does my active reduce cellular ROS production ?
Oxidative stress is due to Reactive Oxygen Species (ROS) that originate from the environment and from the organ itself. Increased production of those free radicals without proper effective action of endogenous and exogenous antioxidant systems generates a condition of oxidative stress. At the digestive level, ROS lead intestinal hyperpermeability by attacking the epithelial junctions. As a result, foods are recognized as allergens, intolerances appear and a chronic inflammation can set in. Moreover, ROS can lead a loss of the microorganisms responsible for fermentation and methanogenesis, and therefore, poor digestion.
