Skin redness is a sign of cutaneous inflammation which can lead to major skin disorders. When the skin is exposed to allergens, irritants, pathogens, or UV rays, cells produce a variety of inflammatory cytokines which bind to specific receptors on target cells. This binding stimulates the production of additional inflammatory signals, playing a key role in immune cell recruitment and activation.
Among the several inflammatory pathways, Nuclear Factor kappa B (NFκB) is a major protein transcription factor that orchestrates inflammation by its translocation from the cytoplasm to the cellular nucleus, allowing the expression of genes encoding inflammation proteins.
In order to assess if your active can protect skin against inflammation, HCS Pharma offers you an in vitro test on HaCaT keratinocytes, allowing you to assess NFκB translocation by immunostaining. See our brochure for more details on this test.
But that’s not all !
Among the cytokines produced in case of inflammation, Interleukin 8 (IL-8) is synthesized by epithelial cells following the detection of potentially pathogenic agents. Its main role is to ensure the recruitment of phagocytic cells to the site of infection in order to eliminate them.
HCS Pharma now offers you a new in vitro test on HaCaT keratinocytes, allowing you to assess IL-8 production by enzyme-linked immuno assay. Same as the NFκB translocation assessment, this test use TNF-α as inducer and an anti-inflammatory reference compound as positive control. See our brochure for more details on this test.
For more information about these tests, please feel free to visit our website or to contact us.
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