We are very please to welcome Dr Isabelle Van Seuningen (Director of CANTHER laboratories & Director of ONCOLille Cancer Institute) and Dr Vincent Senez (Research Director CNRS/CANTHER Laboratory/ONCOLille Institute) in our serie of talk about the uses of BIOMIMESYS®. They explain why they use this technology on cancer research with Read more…
Abstract The extracellular polysaccharide hyaluronan (HA) controls cell migration, differentiation and proliferation, and contributes to the invasiveness of human cancers. The roles of HA cell surface receptors and hyaluronidases (HAses) in this process are still controversial. In order to investigate their involvement in cancer pathogenesis, we developed a reticulated HA Read more…
New results of growing of breast cancer (MCF7 and MCF7-sh-wisp2) cells in BIOMIMESYS® Adipose tissue as a relevant 3D in vitro model, using Keller–Segel PDE system to model chemotactical auto-organization of cells. Abstract Three-dimensional cultures of cells are gaining popularity as an in vitro improvement over 2D Petri dishes. In many such experiments, Read more…
We warmly thanks Dr Samuel Meignan for this short talk about BIOMIMESYS®. You can find below the translation in French and English (and you can change captions on the video). English (French is below) I’m Dr. Samuel Meignan I’m a researcher in biology, specialized in cancerology, and I’m the head Read more…
We are happy to tell you that HCS Pharma, SMMiL-E team (Seeding Microsystems in Medecine in Lille – European-Japanese Technologies against Cancer, CNRS UMI-2820 LIMMS/IIS) and Institut d’Electronique, de Micro-Electronique et de Nanotechnologie (IEMN) have successfully applied to a LabCom grant (‘COMmon LABoratory’)! A LabCom aims at gathering two entities Read more…
It is now well described that in tumor biopsies, the stiffness of the cancerous tissue is higher than the surrounding non-cancerous tissue of the same organ, with a described remodeling of the ECM. The increase in rigidity is related to the stimulation of fibroblasts that increase the synthesis of glycosaminoglycans, Read more…
The extracellular matrix (ECM) is known as a molecular network of macromolecules present in all solid tissues (Figure 1), which plays an important role in the growth, migration and differentiation of cells. This ECM is part of a complex and plastic microenvironment in health and disease: its composition and physical Read more…
A controversial study about links between tumors and genetic mutations
Quantifying DNA damage is mandatory to assess potential adverse effects of candidate drugs or molecules or extracts developed in the dermo-cosmetic industry, but also to assess the efficacy of therapeutic approaches with the aim of producing tumor cell genotoxicity in cancer treatment.