We are delighted to announce that a very interesting study using BIOMIMESYS® to study the metastasis of breast cancer has been published in Experimental Hematology & Oncology Journal (Impact factor 11,4). This article untitled “ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells” (Cicero, Read more…
Yesterday Julien Cicero defended his PhD thesis in OncoLille Institute, about the role of neurotrophins and related receptors in brain metastasis of triple negative breast cancer. What a great thesis defense, we enjoyed a lot his very clear presentation and his responses to the questions of the committee. Perfect time Read more…
HCS Pharma is pleased to publish 3 new brochures on various services in pharmacolgy : Click here to access the brochure if you are interested in !
Julien Cicero, with whom we are collaborating about the study of breast cancer metastasis mechanisms, was proud to present his PhD work during the last EACR conference. It was held in Torino (Italy) last month, during which Julien could discuss with cancer researchers from all around the world. His poster Read more…
Poster presented during the SLAS Building Biology in 3D symposium event in Cambridge on April, 21th 2023. Title: 3D cell culture taking into account the extracellular matrix for phenotypic screening in the frame of Parkinson’s disease V. De Conto 1*, Cheung V.1, Alejandra Mogrovejo – Valdivia1, Maubon N.1, Vandenhaute E.1, Read more…
We will be pleased to meet you in Paris from the 28th to 30th of March. Join Thierry DE CATHEU Business Director, Mathieu LAOUENAN Chief Commercial Officer, Paul COUVREUR and Rita HIEN Junior Business Developpers. Meryl Roudaut, our Project leader in metabolic tissues, and our Project director Elodie VANDENHAUTE will Read more…
The Brain Week is an international event organized simultaneously in about 100 countries and more than 120 cities in France. Its aim is to raise public awareness of the importance of brain research. It is an opportunity for many researchers to meet the public and share with them the advances Read more…
The congress of European Society of Toxicology In Vitro (ESTIV) took place from 21st to 25th November 2022. This congress is focus on the alternative methods to animal testing, including both in silico and in vitro modeling. After a nice opening ceremony with a flamenco show, the scientific program begun Read more…
We are pleased to participate to the 21st International Congress of the European Society of Toxicology In Vitro (ESTIV 2022), which will take place in Barcelona-Sitges, Spain, from 21st to 25th November 2022. Our project Leader in in vitro pharmacology Véronique De Conto will present her poster entitled “In vitro microenvironment modifies the neurotoxic Read more…
This is the end of the 6-month internship of Natacha in HCS Pharma, about the microenvironment modifications in Parkinson’s disease. Indeed, in vivo studies in the literature showed that the neuronal death in Parkinson’s disease involved Extracellular Matrix (ECM) modifications, including an increase in some components like collagen and a Read more…
About 90% of drug candidates fail in clinical trials, for efficacy- and toxicity-related reasons, which often involve the Central Nervous System (CNS). This high failure rate highlights a lack of relevance in experimental models used upstream, including human in vitro models. Indeed, they do not take into account the complexity Read more…
From different studies we know that more than 92% of drug candidates for Central Nervous System diseases fail in clinical trials, with 34% of safety failure. All that candidates have successfully passed in vitro steps and animal testing. Conclusion is straightforward : we have to deeply change biological models in Read more…
Presentation in english Environ 90 % des candidats médicaments échouent aux essais cliniques, notamment en neurologie, faute d’efficacité. Cela met en évidence un manque de pertinence dans les modèles précliniques, y compris les modèles in vitro, qui ne prennent pas en compte le microenvironnement, composé par les cellules gliales et Read more…
Présentation en français About 90% of drug-candidates failed in clinical trials, in particular in neurology, due to a lack of efficacy. That highlights a lack of relevance in preclinical models, including in vitro models, which do not take into account the microenvironment, composed by glial cells and the Extracellular Matrix Read more…
When Tuesday, October 4, 2022 – 9AM (CEST) / 3PM (CST) / 4PM (JST) / 3AM (EST) Thursday, October 6, 2022 – 1:30PM (CEST) / 7:30PM (CST) / 8:30PM (JST) / 7:30AM (EST) Where Online, using zoom.us and live on Youtube What About 90% of drug candidates fail in clinical Read more…
The Federation of European Neuroscience Societies (FENS) forum 2022 took place in Paris, from 9 to 15 July. This event gathers nearly 8,000 neuroscientists from 92 countries. Twenty-two plenary and special lectures were given in 8 conferences room, about various topics in neurosciences, like brain imaging methods, brain development (synapse Read more…
Aim: About 90% of drug-candidates failed in clinical trials, in particular in neurology, due to a lack of efficacy. That highlights a lack of relevance in preclinical models, including in vitro models, which do not take into account the microenvironment, composed by glial cells and the Extracellular Matrix (ECM). The Read more…
Our project leader in in vitro pharmacology Veronique De Conto will be present to the Federation of European Neurosciences Societies (FENS) congress, from 9 to 13 July in Paris. She will present a poster about the importance of microenvironment in cerebral in vitro models for phenotypic screening, in the frame Read more…
Elodie Vandenhaute (our project director), Véronique De Conto (our project leader in in vitro pharmacology) and Natacha Perrin (our trainee in neurosciences) were present at the annual SCMC (Société Cerveau et Maladies Cérébrovasculaires – The French Brain and Cerebrovascular Diseases Society) congress, which took place on the 16th of June Read more…
Yesterday, the 11th of April, was the World Parkinson’s Day. On this occasion, HCS pharma would like to inform you about this disease and its work for new drug discovery. What is Parkinson’s disease? It is the second most common neurodegenerative disease after Alzheimer’s disease. It is attributed to a Read more…
