The neurovasculaire unit (NVU) is composed of brain microvascular endothelial cells (BMECs) that form the Blood-Brain-Barrier (BBB), pericytes, neurons and glial cells. It regulates substance transport between blood and brain. BBB and NVU dysfonctions are associated with numerous neurological pathologies. Animal models are traditionally used in medical research but the Read more…
A new BIOMIMESYS® hydroscaffold is available for 3D cell culture! This hydroscaffold is suitable for neuronal cell culture. We tested it for two cell lines: SH-SY5Y cells, commonly used for pharmaceutical research, and LUHMES cells (dopaminergic neurons). Cells grow and form spheroids with intra and inter-spheroidal neurites. BIOMIMESYS® hydroscaffold allows Read more…
Review of Human neuro-astrocytes 3D co-culture-based assay for evaluation of neuroprotective compounds (Terrasso et al. 2017) Terrasso et al. published a study about a neuroprotection assay on a 3D model in 2017. They developed a 3D co-culture of neurons and astrocytes by means of an agitation-based culture system. Then they Read more…
Sood et al. published in 2016 an interesting article about the effect of extracellular matrix (ECM) on in vitro neuronal cells culture: “Fetal brain extracellular matrix boosts neuronal network formation in 3D bioengineered model of cortical brain tissue “. The aim of the study was to study the effects of Read more…
Our study directors Elodie and Pierre-Jean will attend “HI Europe” in Frankfurt next week. We cordially invite you to discuss with them, they will be happy to present our imaging services related to nutraceutical testing! We are equipped to test from one to thousands of ingredients on any of our state-of-the-art Read more…
Hepatocytes in primary cultures are still the gold standard in the pharmaceutical industry ; however they are expensive and have a very short lifespan with a progressive loss of specific functions over time. The dipolar aprotic solvent, dimethyl sulfoxide (DMSO) is wildly used to stabilize the liver specific function of Read more…
HCS pharma has organized its second scientific advisory board! We were pleased to gather around the table (physically or via a Webex visioconference for those who could not make the trip) David Devos, Roméo Cecchelli, George Haase, Karim Si Tayed… and a new board member: Dominique Collard! Dominique is known Read more…
Next week, we will be in the beautiful city of Lyon to participate to Forum Labo with our partners Molecular Devices and INTEGRA Biosciences. In this event we will present our brand new BIOMIMESYS® technology for 3D cell culture on INTEGRA Biosciences’s booth (#B18). This is an unique and natural Read more…
Adipose tissue is vitally important to various normal processes of the human body, and it has also many implications for human disease states. Obesity is a common health problem and is considered as a major risk factor for non insulin-dependent diabetes mellitus, cardiovascular diseases and hypertension. Obesity is a well-known Read more…
Half of all drugs fail in Phase II and Phase III clinical trials due to a lack of efficacy !
A review of biomaterials technologies for 3D cell culture
For ethical and cost-related reasons, use of animals for the assessment of mode of action, metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in research and industrial applications. Physiologically based pharmacokinetic (PBPK2) modeling is the most potent in silico tool used for extrapolation of pharmacokinetic parameters to Read more…
A new ink with live bacteria is developed at ETH
This event has again shown the importance of micro-environment with modification of the extracellular matrix
Come and discover our programs on iPS and 3D culture
Our CEO will be in Boston from Monday (November 7) to Wednesday (November 9).
3D culture, patients derived culture as iPS, phenotypic screening, machine learning to go to personalized medicine …
As shown by AstraZeneca in nature reviews*, one third of safety failures along the drug discovery process is linked to CNS toxicity uncovered in clinical trials. To avoid this attrition, the potential neurotoxicity of any drug going through the blood brain barrier (BBB) needs to be assessed in the very early stages Read more…
We will talk about advantages of 3D culture in phenotypic screening
Méryl Roudaut* will present a poster on the work of Institut du Thorax
According to a report issued by the Tufts Center for the Study of Drug Development, the costs associated with bringing a novel drug to market exceed $2.5 billion per successful compound
Biosynthetic skeleton for ECM development.