Extracellular matrix (ECM) is known to have an influence on physiological processes and on tumour progression: ECM properties (composition, stiffness) modulate cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT). For example, EMT is inhibited by laminin-rich environment whereas it is promoted in fibronectin-rich ECM (Chen et al 2013. Differentiation 86, Read more…
Sood et al. published in 2016 an interesting article about the effect of extracellular matrix (ECM) on in vitro neuronal cells culture: “Fetal brain extracellular matrix boosts neuronal network formation in 3D bioengineered model of cortical brain tissue “. The aim of the study was to study the effects of Read more…
In this article, researchers from Sorbonne University (Paris, France) proposed an explanation for the patterns followed by breast cancer cells when seeded in BIOMIMESYS, i.e. spherical aggregates. Usually, mathematical models dealing with the formation of patterns by cells in the extracellular matrix do not take into account the chemical environmental Read more…
The 2nd Edition of SLAS advanced 3D human models and High-Content Analysis Conference was a great event with interesting presentations and posters from public labs and various companies. In regards of the different presentations, it seems obvious that developing 3D cell culture models is essential to find new leads relevant Read more…
It is a great pleasure for us to welcome a new member in our scientific advisory board, Dr Samuel Meignan! He will for sure help us to develop relevant models related to oncology therapeutic area. Dr. Samuel Meignan is a senior researcher at the Inserm U908 laboratory ‘Cell Plasticity and Read more…
Next week, we will be in the beautiful city of Lyon to participate to Forum Labo with our partners Molecular Devices and INTEGRA Biosciences. In this event we will present our brand new BIOMIMESYS® technology for 3D cell culture on INTEGRA Biosciences’s booth (#B18). This is an unique and natural Read more…
Extracellular matrix is a key point to find new therapeutic drugs