James W. Fawcett published the review « The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease » in 2015, highlighting the key role of the chondroitin sulfate proteoglycans (CSPGs) of the extracellular matrix (ECM) in brain plasticity. CSPGs are present in the brain extracellular matrix and Read more…
The annual congress of Biology and Health PhD students from Lille (André Verbert day) took place at the Faculty of Medicine Thursday, September 10th. During this day, PhD students, in third year of thesis, had to present their works by talks, flash-talks or posters. Our PhD student Véronique De Conto Read more…
The extracellular matrix (ECM) is known as a molecular network of macromolecules present in all solid tissues (Figure 1), which plays an important role in the growth, migration and differentiation of cells. This ECM is part of a complex and plastic microenvironment in health and disease: its composition and physical Read more…
In the continuity of our scientific reviews about the important roles of Hyaluronic Acid (HA) in extracellular matrix (ECM) and cell behavior, we herein present this recent review describing the structure – function relationship of HA. As an important polysaccharide of ECM, HA plays an important role in cell and Read more…
We will be present this week and next week in Rotterdam, to talk about 3D cell culture and the importance of the microenvironnement in the relevance of in vitro models. As you known, to mimic human tissues, several parameters need to be taken into account: the target cells, nutrient intake Read more…
The 16th SFBMEC congress was held last week in Reims: Elodie and Zied attended the meeting to be aware of the last trends in extracellular matrix (ECM) research and industry and medical applications. And they were not disappointed! After a first touching lecture in memoriam of the late Ladislas Robert Read more…
Extracellular matrix (ECM) is known to have an influence on physiological processes and on tumour progression: ECM properties (composition, stiffness) modulate cell proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT). For example, EMT is inhibited by laminin-rich environment whereas it is promoted in fibronectin-rich ECM (Chen et al 2013. Differentiation 86, Read more…
Sood et al. published in 2016 an interesting article about the effect of extracellular matrix (ECM) on in vitro neuronal cells culture: “Fetal brain extracellular matrix boosts neuronal network formation in 3D bioengineered model of cortical brain tissue “. The aim of the study was to study the effects of Read more…
In this article, researchers from Sorbonne University (Paris, France) proposed an explanation for the patterns followed by breast cancer cells when seeded in BIOMIMESYS, i.e. spherical aggregates. Usually, mathematical models dealing with the formation of patterns by cells in the extracellular matrix do not take into account the chemical environmental Read more…
The 2nd Edition of SLAS advanced 3D human models and High-Content Analysis Conference was a great event with interesting presentations and posters from public labs and various companies. In regards of the different presentations, it seems obvious that developing 3D cell culture models is essential to find new leads relevant Read more…
It is a great pleasure for us to welcome a new member in our scientific advisory board, Dr Samuel Meignan! He will for sure help us to develop relevant models related to oncology therapeutic area. Dr. Samuel Meignan is a senior researcher at the Inserm U908 laboratory ‘Cell Plasticity and Read more…
Next week, we will be in the beautiful city of Lyon to participate to Forum Labo with our partners Molecular Devices and INTEGRA Biosciences. In this event we will present our brand new BIOMIMESYS® technology for 3D cell culture on INTEGRA Biosciences’s booth (#B18). This is an unique and natural Read more…
Extracellular matrix is a key point to find new therapeutic drugs