It is now well described that in tumor biopsies, the stiffness of the cancerous tissue is higher than the surrounding non-cancerous tissue of the same organ, with a described remodeling of the ECM. The increase in rigidity is related to the stimulation of fibroblasts that increase the synthesis of glycosaminoglycans, Read more…
Biomimesys is providing a great opportunity to culture human induced pluripotent stem cells (hiPSCs) in 3D and differentiate them into different kind of cell types including liver cells. Showcased by Méryl Roudaut at the 20th International Congress on In Vitro Toxicology (ESTIV2018), our co-development with the institute du thorax (U1087) Read more…
Ask for high quality link by putting your email below We previously showed that human pluripotent stem cells (hiPSCs) provide a suitable model to study metabolic diseases upon hepatocyte-like cell (HLC) differentiation. In particular, HLCs have been used to model cholesterol metabolism regulation, by mimicking the main disease features in Read more…
Stroke is the second leading cause of death worldwide and the most common cause of disability in adults. Ischemic stroke represents 80% of the cases. They cause oxygen and glucose deficit in the brain, leading to necrosis, edema formation, inflammation and apoptosis. Endogenous repair mechanisms, like cerebral plasticity, limit ischemia-linked Read more…
Nathalie and Elodie were in Marseille last week for BioFit event, where we had a booth under Clubster NHL (Nutrition-Health-Longevity) Pavilion: We would like to thank all the participants and collaborators who came to see us… We really enjoyed spending these 2 days with our neighbours from InEye-Pharma and ImmuneInsight: Read more…
Nathalie and Elodie will be present in Marseille for BioFit event next week! Indeed, HCS Pharma has a booth in Clubster NSL’s pavilion (number I20). Just stop by 🙂 It will be a pleasure to talk to you about the innovative 3D cell culture matrix BIOMIMESYS® and our related services Read more…
If you work in 3D cell culture, you should know our innovative technology BIOMIMESYS® just recognized as a Deep Tech Pionner by Hello Tomorrow. We have more and more practical examples of uses by our customers and we want to help them to be more efficient in the “everyday labo Read more…
We were in Taiwan few weeks ago, invited by our partner Molecular Devices to talk about our skills in 3D cell culture, with our unique groundbreaking technology BIOMIMESYS® and our services for in vitro screening from cell assay development to picture and data analysis. It was also a perfect opportunity Read more…
With more than 25 countries represented, NutrEvent is THE place to be for business and innovation in Food, Nutrition and Health. It will take place next week in Rennes congress centre (Couvent des Jacobins), on the 22nd and 22rd of October. Our stand will be on Eurasanté Pavilion (Level 1 Read more…
With more than 1100 researchers and exhibiting experts, “Rendez-vous Carnot” offers a complete ecosystem of R&D and innovation support. We will attend at two-day Rendez vous CARNOT (October 16-17 in Paris) to present our innovations on 3D cell culture with our unique and proprietary technology BIOMIMESYS®… Also we will present our activities Read more…
We are very happy to share with you about HCS and 3D in vitro models thanks to a labroots.com webinar on October 27, 2019! This webinar is made with our partner Molecular Devices and it will present you many tips on how to handle 3D cell culture systems such as Read more…
We previously showed that human pluripotent stem cells (hiPSCs) provide a suitable model to study metabolic diseases upon hepatocyte-like cell (HLC) differentiation. In particular, HLCs have been used to model cholesterol metabolism regulation, by mimicking the main disease features in vitro. Human iPSCs can be generated from urine samples of Read more…
In HCS Pharma, we have already talked about Artificial Intelligence (AI) and the way it is useful in picture analysis. AI can obviously be used for many endeavours, like the shortening of drug discovery timeline as it is explained in the article “Deep learning enables rapid identification of potent DDR1 Read more…
Last week we were glad to attend TERMIS-EU workshop in Nantes, dealing with 3D bioprinting in cancer research. There we presented 3 posters – that you can find on our website! – about BIOMIMESYS® product range, about iPSC-derived hepatocytes in BIOMIMESYS® Liver, and about BIOMIMESYS® for organ-on-chip systems… Moreover, we Read more…
Objective: to develop a new liver-on-chip model that includes a relevant 3D matrix for hepatic cell growth and function with the use of of BIOMIMESYS® Liver hydroscaffold for a physiological 3D hepatocyte culture. Ask for high quality link by putting your email below View and download on Slideshare (low quality) Read more…
We will attend Termis workshop (August 26-27 in Nantes, France) to present our innovations on 3D cell culture and, of course, our brand new BIOMIMESYS® products! In our new poster, you will find how we used BIOMIMESYS® Liver hydroscaffold to create a liver-on-chip for mimicking the liver extracellular matrix. We Read more…
The extracellular matrix (ECM) is known as a molecular network of macromolecules present in all solid tissues (Figure 1), which plays an important role in the growth, migration and differentiation of cells. This ECM is part of a complex and plastic microenvironment in health and disease: its composition and physical Read more…
Last week we were pleased to attend the founding congress of STCM (Société de Toxicologie Cellularie et Moléculaire), which was held in FIAP Jean Monnet (Paris). The topic was “Toxicology towards the 3rd dimension“. With a wide variety of talks from academic laboratories and from the industry, the content was Read more…
The founding congress of the french STCM (Société de Toxicologie Cellulaire et Moléculaire) will take place in Paris at the end of this week (13th-14th June, 2019). The theme of this meeting will be “Toxicology towards the 3rd dimension“. We are looking forward to attending this congress, and to becoming Read more…
We will be present this week and next week in Rotterdam, to talk about 3D cell culture and the importance of the microenvironnement in the relevance of in vitro models. As you known, to mimic human tissues, several parameters need to be taken into account: the target cells, nutrient intake Read more…
The extracellular matrix (ECM) is a three-dimensional macromolecular network composed of structural proteins (collagens, elastin), adhesion/signalling proteins (fibronectin, laminins), different proteoglycans, glycoproteins and glycosaminoglycans (GAGs). GAGs are structurally complex, but their structure is simply made up of repeating disaccharide building blocks composed of alternating uronic acid and hexosamine units. GAGs Read more…
Even if microbiota-relateds treatments are quite recent in the therapeutical field, at least 2,400 clinical trials were launched in 2018! Gut, skin and oncology microbiota will be definitively be the hot topic in the next 10 years. Of course, we are heavily working in the field, with a focus on Read more…
The 16th SFBMEC congress was held last week in Reims: Elodie and Zied attended the meeting to be aware of the last trends in extracellular matrix (ECM) research and industry and medical applications. And they were not disappointed! After a first touching lecture in memoriam of the late Ladislas Robert Read more…