Our project director Elodie is participating to EUSAAT congress in Linz (Austria) this week, the European Congress on Alternatives to Animal Testing. She will have the pleasure to present our work aiming at bridging the gap between in vivo and in vitro situations by taking into account the extracellular matrix Read more…
BIOMIMESYS® Liver recreates the complex cellular microenvironment of the liver to extend longevity and functionality of hepatocytes in culture: The life of human primary hepatocytes grown in a 2D sandwich is low, 3-10 days (1) and is accompanied by dedifferentiation, leading to the loss of their functions. In 2D culture, Read more…
2D cell culture has been used for more than 100 years now, to keep cells outside of their original organism and to use them for different purposes. It is still widely used in research and early steps of the drug discovery process, and has allowed a bunch of discoveries so Read more…
As you might know, October is the Breast Cancer Awareness Month, an annual campaign to raise awareness about the impact of breast cancer. Research is the key tool to fight this disease and we are very happy to collaborate with amazing research teams in this fight. Since last year, our Read more…
Summer is alway a good time to improve our services. Then we are very happy to introduce our updated Skin Pigmentation and Oxidative Stress services. Pigmentation is particularly regulated at the cellular level by melanocytes synthesizing melanin within melanosomes, which can be produced in varying sizes, numbers, and densities. In order to evaluate Read more…
The annual congress of the SCMC (Societé Cerveau et Maldies Cérébraux Vasculaires – Brain and cerebrovascular diseases Society) will take place this Friday, may 28 2021 (virtual congress). On this occasion, our PhD student Véronique De Conto will present her PhD works, which concern the development of new cerebral in Read more…
Abstract The extracellular polysaccharide hyaluronan (HA) controls cell migration, differentiation and proliferation, and contributes to the invasiveness of human cancers. The roles of HA cell surface receptors and hyaluronidases (HAses) in this process are still controversial. In order to investigate their involvement in cancer pathogenesis, we developed a reticulated HA Read more…
In this tutorial you will see how to seed a BIOMIMESYS® plate with a VIAFLO 384 from INTEGRA Biosciences (https://www.integra-biosciences.com/france/en/electronic-pipettes/viaflo-96384)
In this tutorial you will see how to seed a BIOMIMESYS® plate with a manual multipipette
In this tutorial you will see how to seed a BIOMIMESYS® plate with a automatic multipipette
In this tutorial you will see how to seed a BIOMIMESYS® plate with a manual monopipette
It’s a large part of our work to reveal beauty (and secrets!) of cells in HCS Pharma thanks to different microscopy technologies. In this nice article, authors present the evolution of this field from first optical devices to most recent high-resolution technologies. It’s interesting to see that observation of cells Read more…
Abstract The extracellular polysaccharide hyaluronan (HA) controls cell migration, differentiation and proliferation, and contributes to the invasiveness of human cancers. In order to investigate the sensitivity of cancer cells to antimitotic agents, we developed a cross-linked HA hydrogel, a three-dimensional matrix in which cells can invade and grow. We have Read more…
For ethical and cost-related reasons, use of animals for the assessment of mode of action, metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in research and industrial applications. Physiologically based pharmacokinetic (PBPK2) modeling is the most potent in silico tool used for extrapolation of pharmacokinetic parameters to Read more…
How to see cells moves ?
I was really happy to be invited in SIBS 2017 in Zurich last week to present our work on 3D cell culture in phenotypic screening and our use of disruptive technologies in our process (augmented reality and virtual reality). I presented our collaborative work with Dr Karim Si-Tayeb, researcher from Read more…
More than 300,000 images available !
Ask for a high quality version of this poster : As shown by AstraZeneca in nature reviews*, one third of safety failures along the drug discovery process is linked to CNS toxicity uncovered in clinical trials. To avoid this attrition, the potential neurotoxicity of any drug going through the blood brain barrier Read more…
3D cell models are now attracting a huge interest from scientists working both on toxicity and pharmacology assay development. They are considered more relevant at mimicking the in vivo situation. However, phenotypic assays on these models can be challenging, and are at least more complex.
Despite continuous improvement of DNA FISH, a method that has been extensively used for years, it still requires harsh treatments to allow probe hybridization.
