Biomimesys
Seeding with a VIAFLO 384 from INTEGRA Biosciences
In this tutorial you will see how to seed a BIOMIMESYS® plate with a VIAFLO 384 from INTEGRA Biosciences (https://www.integra-biosciences.com/france/en/electronic-pipettes/viaflo-96384)
Biomimesys
Seeding with manual multipipette
In this tutorial you will see how to seed a BIOMIMESYS® plate with a manual multipipette
Biomimesys
Seeding with automatic multipipette
In this tutorial you will see how to seed a BIOMIMESYS® plate with a automatic multipipette
Biomimesys
Seeding with a monopipette
In this tutorial you will see how to seed a BIOMIMESYS® plate with a manual monopipette
HCS, HCA & Biology
Revealing the Secret Lives of Cells With Advanced Microscopy
It’s a large part of our work to reveal beauty (and secrets!) of cells in HCS Pharma thanks to different microscopy technologies. In this nice article, authors present the evolution of this field from first optical devices to most recent high-resolution technologies. It’s interesting to see that observation of cells Read more…
HCS, HCA & Biology
Drug discovery : Need of reliable IVIVE for pharmacodynamics and pharmacokinetics assessment
For ethical and cost-related reasons, use of animals for the assessment of mode of action, metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in research and industrial applications. Physiologically based pharmacokinetic (PBPK2) modeling is the most potent in silico tool used for extrapolation of pharmacokinetic parameters to Read more…
HCS, HCA & Biology
Internal forces directing cell migration are revealed by live-cell microscopy
How to see cells moves ?
News
Feedback of SIBS 2017 in Zurich last week
I was really happy to be invited in SIBS 2017 in Zurich last week to present our work on 3D cell culture in phenotypic screening and our use of disruptive technologies in our process (augmented reality and virtual reality). I presented our collaborative work with Dr Karim Si-Tayeb, researcher from Read more…
HCS, HCA & Biology
Cell Atlas, a comprehensive image-based map of the subcellular protein distribution
More than 300,000 images available !
Posters
Poster – Neurotoxicity assay on 2D and 3D culture using High Content Screening (HCS) technology
Ask for a high quality version of this poster : As shown by AstraZeneca in nature reviews*, one third of safety failures along the drug discovery process is linked to CNS toxicity uncovered in clinical trials. To avoid this attrition, the potential neurotoxicity of any drug going through the blood brain barrier Read more…
HCS, HCA & Biology
Phenotypic characterization on liver spheroïds
3D cell models are now attracting a huge interest from scientists working both on toxicity and pharmacology assay development. They are considered more relevant at mimicking the in vivo situation. However, phenotypic assays on these models can be challenging, and are at least more complex.
HCS, HCA & Biology
New promising method for in situ labeling of genomic loci in fixed cells
Despite continuous improvement of DNA FISH, a method that has been extensively used for years, it still requires harsh treatments to allow probe hybridization.
News
Wound healing assay development in dermocosmetology
Cell biology is part of the R&D activity in dermocosmetology. At HCS Pharma, we are developing dermocosmetology assay using our automation platform and high content analysis software.
Posters
Poster – Development of double stand break assessment assay with HCS by using the HepG2 cell line and evaluation with primary skin cell (NHEK)
The creation of a double strand break (DSB) is accompanied by the phosphorylation of histone H2AX. The measurement of serine 139 phosphorylated histone H2AX (γH2AX) is reported to be a marker of interest to identify potential genotoxic activity.
HCS, HCA & Biology
To look inside the cell with SIM (structured illumination microscopy)
Thomas Kirchhausen, Eric Betzig et al. publish an article in Sciences about SIM (structured illumination microscopy) and the observation of moving molecules inside cells. The incredible spatial and time resolution give the opportunity to see for exemple proteins which pass the cell membrane.
HCS, HCA & Biology
Single-Cell Genomics Allows Identification of New Cell Types
Aviv Regev at the Broad Institute, in Cambridge, use fluidic systems to separate cells and submits them to detailed genetic analysis, at the rate of thousands per day. The goal is to build a comprehensive cellular atlas of the human, based on gene expression profile.
